Imaging the human tympanic membrane using optical coherence tomography in vivo.
Imaging the human tympanic membrane using optical coherence tomography in vivo.
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DOI：
10.1097/mao.0b013e31818a08ce
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发表时间：
2008-12
期刊：
影响因子：
--
通讯作者：
Wong BJ
中科院分区：
文献类型：
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作者：
Djalilian HR;Ridgway J;Tam M;Sepehr A;Chen Z;Wong BJ
光学相干层析成像(OCT)是一种诊断性成像方式，它将低相干光与干涉测量相结合，以产生高分辨率的活体组织断层图像。利用这项技术，我们在办公室临床环境中对人鼓膜(TM)进行了活体成像，并表征了正常和病理条件下的TM微观结构。前瞻性临床试验。对10例成年受试者的TMS进行了正常和病变的检查。每个受试者在OCT成像前都接受了直接显微镜检查，以提供相关亚部位的视觉配准，包括纤维环、延伸部、软化部和Umbo。将来自成像系统的探头(中心波长1,310 nm，15μm相干长度，NIRIS；美国，克利夫兰，俄亥俄州伊马卢克斯)引入耳道，获得侧位断层图像。对TM进行系统成像，并对上皮层和胶原层进行表征。总的TM厚度被清楚地显示和量化。在耳部疾病的治疗中，非侵入性研究活体中耳微结构的能力是必不可少的。OCT可为耳科医生/神经科医生提供以下能力：1)对胆脂瘤、二聚体TMS和慢性中耳炎等病理进行成像；2)评估药物治疗的反应；3)监测鼓室成形术和其他手术后的变化。OCT可能为优化中耳疾病患者的诊断和治疗提供一种手段。
Optical coherence tomography (OCT) is a diagnostic imaging modality that combines low coherence light with inter ferometry to produce high-resolution cross-sectional images of living tissues. Using this technology, we have imaged in vivo the human tympanic membrane (TM) in the office clinic setting and characterized TM microstructure in normal and pathologic conditions. Prospective clinical trial. The normal and diseased TMs in 10 adult subjects were examined. Each subject underwent direct microscopic examination before OCT imaging to provide visual coregistration of associated subsites including the anulus fibrosus, pars tensa, pars flaccida, and umbo. The probe from the imaging system (1,310-nm central wavelength, 15-μm coherence length, Niris; Imalux, Cleveland, OH, USA) was introduced into the ear canal to obtain lateral cross-sectional images. Systematic imaging of the TM was performed with characterization of the epithelial and collagenous layers. The overall TM thickness was clearly demonstrated and quantified. The ability to noninvasively study middle ear microstructures in vivo is essential in the treatment of diseases of the ear. OCT may provide the otologist/neurotologist with the ability to 1) image pathology such as cholesteatoma, dimeric TMs, and chronic otitis media; 2) gauge the response to pharmacological therapy; and 3) monitor postsurgical changes after tympanoplasty and other procedures. OCT may provide a means to optimize the diagnosis and management of patients with middle ear disease.