Decreased Endothelial Nitric Oxide Bioavailability, Impaired Microvascular Function, and Increased Tissue Oxygen Consumption in Children With Falciparum Malaria
Decreased Endothelial Nitric Oxide Bioavailability, Impaired Microvascular Function, and Increased Tissue Oxygen Consumption in Children With Falciparum Malaria
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DOI：
10.1093/infdis/jiu308
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发表时间：
2014-11-15
影响因子：
6.4
通讯作者：
Anstey, Nicholas M.
中科院分区：
文献类型：
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作者：
Yeo, Tsin W.;Lampah, Daniel A.;Anstey, Nicholas M.
内皮细胞一氧化氮（NO）的生物利用度，微血管功能，和主机耗氧量尚未在儿童疟疾进行评估。我们测量了NO依赖性内皮功能，采用外周动脉张力测定法，以确定反应性充血指数（RHI），微血管功能和氧耗量（VO 2），采用近红外共振光谱在13例印尼儿童严重恶性疟疾和15例中重度恶性疟疾。与19名对照组相比，重度疟疾和中度疟疾儿童的RHI较低（P = 0.03）;微血管功能分别降低12%和8%（P = 0.03）; VO 2分别增加29%和25%。在所有疟疾患儿（P <0.001）和所有重症疟疾患儿（P <0.001）中，RHI与微血管功能相关。患有疟疾的儿童内皮和微血管功能下降，耗氧量增加，可能有助于疾病的发病机制。
Endothelial nitric oxide (NO) bioavailability, microvascular function, and host oxygen consumption have not been assessed in pediatric malaria. We measured NO-dependent endothelial function by using peripheral artery tonometry to determine the reactive hyperemia index (RHI), and microvascular function and oxygen consumption (VO2) using near infrared resonance spectroscopy in 13 Indonesian children with severe falciparum malaria and 15 with moderately severe falciparum malaria. Compared with 19 controls, children with severe malaria and those with moderately severe malaria had lower RHIs (P = .03); 12% and 8% lower microvascular function, respectively (P = .03); and 29% and 25% higher VO2, respectively. RHIs correlated with microvascular function in all children with malaria (P < .001) and all with severe malaria (P < .001). Children with malaria have decreased endothelial and microvascular function and increased oxygen consumption, likely contributing to the pathogenesis of the disease.