Genetic diversity of hepatitis B virus strains derived worldwide:: Genotypes, subgenotypes, and HBsAg subtypes
Genetic diversity of hepatitis B virus strains derived worldwide:: Genotypes, subgenotypes, and HBsAg subtypes
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DOI：
10.1159/000080872
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发表时间：
2004-01-01
期刊：
影响因子：
4.6
通讯作者：
Magnius, LO
中科院分区：
文献类型：
--
作者：
Norder, H;Couroucé, AM;Magnius, LO
利用234个全基因组和631个B型肝炎表面抗原基因的序列分析了世界范围内B型肝炎病毒（HBV）的多样性。除了所述的A和F各两种亚基因型外，在完整基因组分析中，B、C和D也各分为四种亚基因型，并得到显著的自助值的支持。B和C亚型的地理分布不同，B1主要分布在日本，B2主要分布在中国和越南，B3仅限于印度尼西亚，B4仅限于越南，所有菌株均指定亚型ayw 1。亚型C1常见于日本、韩国和中国; C2常见于中国、东南亚和孟加拉国，C3常见于大洋洲，包括指定adrq-的菌株，C4指定ayw 3在澳大利亚的土著人中出现。这种明确的地理分布模式在D1-D4中不太明显，其中亚基因型在欧洲、非洲和亚洲广泛分布，可能是由于它们的分歧发生在比基因型B和C更早的时间之前，D4是D在大洋洲的第一个分裂并且仍然是主要的亚基因型。HBV的遗传多样性及其亚型的地理分布为重建HBV的进化历史提供了一种工具，并可能有助于补充遗传数据，以了解人类的进化和过去的迁移。Karger AG，巴塞尔。
Sequences of 234 complete genomes and 631 hepatitis B surface antigen genes were used to assess the worldwide diversity of hepatitis B virus (HBV). Apart from the described two subgenotypes each for A and F, also B, C, and D divided into four subgenotypes each in the analysis of complete genomes supported by significant boot-strap values. The subgenotypes of B and C differed in their geographical distribution, with B1 dominating in Japan, B2 in China and Vietnam, B3 confined to Indonesia, and B4 confined to Vietnam, all strains specifying subtype ayw1. Subgenotype C1 was common in Japan, Korea, and China; C2 in China, South-East Asia, and Bangladesh, and C3 in the Oceania comprising strains specifying adrq-, and C4 specifying ayw3 is encountered in Aborigines from Australia. This pattern of defined geographical distribution was less evident for D1-D4, where the subgenotypes were widely spread in Europe, Africa, and Asia, possibly due to their divergence having occurred a longer time ago than for genotypes B and C, with D4 being the first split and still the dominating sub-genotype of D in the Oceania. The genetic diversity of HBV and the geographical distribution of its subgenotypes provide a tool to reconstruct the evolutionary history of HBV and may help to complement genetic data in the understanding of the evolution and past migrations of man. Copyright (C) 2004 S. Karger AG, Basel.