Uptake of community-based, self-collected HPV testing vs. visual inspection with acetic acid for cervical cancer screening in Kampala, Uganda: preliminary results of a randomised controlled trial
Uptake of community-based, self-collected HPV testing vs. visual inspection with acetic acid for cervical cancer screening in Kampala, Uganda: preliminary results of a randomised controlled trial
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DOI：
10.1111/tmi.12549
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发表时间：
2015-10-01
影响因子：
3.3
通讯作者：
Ogilvie, Gina S.
中科院分区：
文献类型：
--
作者：
Moses, Erin;Pedersen, Heather N.;Ogilvie, Gina S.
目的比较两种宫颈癌筛查方法：社区自行采集高危人乳头瘤病毒（HR-HPV）检测和醋酸目视检查（VIA）。方法对乌干达基塞尼社区 500 名 30-65 岁女性进行随机对照试验。随机接受基于自我采集的 HR-HPV 检测的女性提供了 HR-HPV 宫颈阴道拭子，实验室检测后通过电话提供结果。 HPV 检测呈阳性的女性被转介到当地卫生部门接受 VIA 治疗。随机接受 VIA 的女性在当地卫生部门接受筛查，根据当地护理标准，VIA 检测呈阳性的女性在筛查时接受冷冻治疗。当有需要时，女性会被转诊进行阴道镜检查。结果测量包括筛查的采用率、HR-HPV 患病率、VIA 结果和治疗率。结果在 HR-HPV 组中，250 例中有 248 例（p
ObjectivesTo compare two cervical cancer screening methods: community-based self-collection of high-risk human papillomavirus (HR-HPV) testing and visual inspection with acetic acid (VIA).MethodsPilot randomised controlled trial of 500 women aged 30-65 in the community of Kisenyi, Uganda. Women randomised to self-collection-based HR-HPV testing provided a cervico-vaginal swab for HR-HPV, and results were provided by phone after laboratory testing. Women who tested HPV positive were referred for VIA at the local health unit. Women randomised to VIA underwent screening at the local health unit, where women who tested positive with VIA were provided cryotherapy at time of screening, as per local standard of care. Women were referred for colposcopy when indicated. Outcome measures were uptake of screening, HR-HPV prevalence, VIA result and treatment rates.ResultsIn the HR-HPV arm, 248 of 250 (p