Link between Interleukin-10 Level and Outcome after Ischemic Stroke
Link between Interleukin-10 Level and Outcome after Ischemic Stroke
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DOI：
10.1159/000290038
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发表时间：
2010-01-01
影响因子：
2.4
通讯作者：
Yip, Hon-Kan
中科院分区：
文献类型：
--
作者：
Chang, Li-Teh;Yuen, Chun-Man;Yip, Hon-Kan
目的：白细胞介素10(IL-10)在急性缺血性卒中(IS)患者中的预后价值尚不清楚。这项研究验证了IS后血清IL-10水平显著升高的假设，并预测了IS的结果。方法：检测135例急性脑梗塞患者、20例健康体检者和30例高危人群血清IL-10水平。结果：IS患者血清IL-10平均水平显著高于两对照组(P<0.0001)。此外，严重神经功能障碍患者的血清IL-10在发病后48小时显著高于轻度神经功能障碍患者(P<；0.0001)。此外，较高的血清IL-10与急性IS后48小时的严重神经功能损害(NIHSS&>=12)密切相关(P<；0.0001)，并独立预测IS后第90天的联合主要不良临床结局(定义为复发IS、任何死因或NIHSS&>=12)(P<；0.0001)。结论：血清IL-10是IS预后的独立预测因子。版权所有(C)2010 S.Karger AG，巴塞尔
Objectives: The prognostic value of interleukin (IL)-10 in patients after acute ischemic stroke (IS) is not well understood. This study tested the hypothesis that serum levels of IL-10 are substantially increased after IS and predictive of IS outcome. Methods: Serum IL-10 levels were examined 48 h after acute IS in 135 consecutive patients, and in 20 healthy and 30 at-risk controls. Results: Mean serum IL-10 was significantly higher in IS patients than in both control groups (p < 0.0001, respectively). Additionally, serum IL-10 was significantly higher in patients with severe neurological impairment [defined as a score 6 12 on the National Institute of Health Stroke Scale (NIHSS)] than in patients with less severe neurological impairment (NIHSS score < 12) 48 h after IS (p < 0.0001). Furthermore, higher serum IL-10 was strongly and independently correlated with severe neurological impairment (NIHSS >= 12) 48 h after acute IS (p < 0.0001), and independently predictive of combined major adverse clinical outcomes (defined as recurrent IS, any cause of death or NIHSS >= 12) on day 90 following IS (p < 0.0001). Conclusions: Serum IL-10 is an independent prognosticator of IS outcome. Copyright (C) 2010 S. Karger AG, Basel