HYPOLIPEMIC AND HYPOGLYCEMIC ACTIVITIES OF PRUNUS-DAVIDIANA IN HIGH FAT-FED RATS
HYPOLIPEMIC AND HYPOGLYCEMIC ACTIVITIES OF PRUNUS-DAVIDIANA IN HIGH FAT-FED RATS
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DOI：
10.1007/bf02857813
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发表时间：
1991-01-01
期刊：
影响因子：
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通讯作者：
PARK H J
中科院分区：
文献类型：
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作者：
CHOI J S;SUH S S;PARK H J
腹腔注射山杏的甲醇提取物后，测定了高脂喂养的高脂血症大鼠的血脂水平。茎。服用甲醇提取物6天后，血液甘油三酯和总胆固醇显着降低，动脉粥样硬化指数也得到改善。除了降血脂作用外，甲醇提取物还被证明可以有效降低高脂喂养引起的高脂血症大鼠的血糖升高水平。另一方面，用原料饲料喂养的大鼠的血液甘油三酯和总胆固醇没有受到施用甲醇提取物的影响，即使有降低的趋势。葡萄糖水平也没有发现显着变化。因此，表明这种甲醇提取物可能只有在摄入过量脂肪时才可能增加代谢利用率。
Blood lipid levels in rats with high fat-fed hyperlipemia were determined after intraperitoneal administration of a methanolic extract of Prunus davidiana Fr. Stems. Administration of the methonalic extract for 6 days produced a significant decrease of blood triglyceride and total cholesterol, and the atherogenic index was also improved. In addition to the hypolipemic effect, the methanolic extract was also shown to be effective in reducing an elevated level of glucose in rats with hyperlipemia resulting from high-fat feeding. On the other hand, blood triglyceride and total cholesterol in rats fed with stock diet were not affected by administration of the methanolic extract even if there was a tendency to decrease. No significant change was also found in the level of glucose. Thus, it is suggested that this methanolic extract probably may increase the metabolic utilization only when fed with excess fat.