dally, a Drosophila glypican, controls cellular responses to the TGF-beta-related morphogen, Dpp.
dally, a Drosophila glypican, controls cellular responses to the TGF-beta-related morphogen, Dpp.
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发表时间：
1997-10
期刊：
影响因子：
4.6
通讯作者：
Shari M. Jackson;H. Nakato;Motoko Sugiura;Alison L. Jannuzi;Rob Oakes;Vesna Kaluza;C. Golden;S. Selleck
中科院分区：
文献类型：
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作者：
Shari M. Jackson;H. Nakato;Motoko Sugiura;Alison L. Jannuzi;Rob Oakes;Vesna Kaluza;C. Golden;S. Selleck
Decapentaplegic (Dpp) 是果蝇生长因子β (TGF-β)/骨形态发生蛋白 (BMP) 超家族的成员。 Dpp 是一种经典的形态发生素，这种分泌因子的浓度梯度控制着许多细胞维度的图案形成。因此，调节 Dpp 信号传导水平对其在发育过程中的功能至关重要。提议调节细胞表面生长因子信号传导的一类分子是整合膜蛋白聚糖。我们在此表明，分裂异常延迟（dally）是发育过程中正常 Dpp 信号传导所需的完整膜蛋白聚糖磷脂酰肌醇家族的果蝇成员，影响细胞对此形态发生素的反应。 dally+ 的异位表达可以改变 Dpp 的模式活性，表明 dally+ 在调节 Dpp 信号强度中发挥作用。这些发现支持磷脂酰肌醇蛋白聚糖家族成员通过影响细胞表面信号传导来控制体内 TGF-β/BMP 活性的作用。
Decapentaplegic (Dpp) is a Drosophila member of the Transforming Growth Factor-beta (TGF-beta)/Bone Morphogenetic Protein (BMP) superfamily of growth factors. Dpp serves as a classical morphogen, where concentration gradients of this secreted factor control patterning over many cell dimensions. Regulating the level of Dpp signaling is therefore critical to its function during development. One type of molecule proposed to modulate growth factor signaling at the cell surface are integral membrane proteoglycans. We show here that division abnormally delayed (dally), a Drosophila member of the glypican family of integral membrane proteoglycans is required for normal Dpp signaling during development, affecting cellular responses to this morphogen. Ectopic expression of dally+ can alter the patterning activity of Dpp, suggesting a role for dally+ in modulating Dpp signaling strength. These findings support a role for members of the glypican family in controlling TGF-beta/BMP activity in vivo by affecting signaling at the cell surface.