Cooperativity between cell contractility and adhesion
Cooperativity between cell contractility and adhesion
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DOI：
10.1103/physrevlett.93.268109
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发表时间：
2004-12-31
影响因子：
8.6
通讯作者：
Loew, LM
中科院分区：
文献类型：
--
作者：
Novak, IL;Slepchenko, BM;Loew, LM
在活细胞中，细胞骨架通过粘着斑（可以感知作用力的多分子结构）与细胞外环境连接。提出了一个模型，第一次解释了为什么局灶性粘连往往在细胞周边的高曲率区域。它是基于粘附形成和肌动球蛋白束（应力纤维）组装之间的正反馈的实验证据。该模型预测，局部粘连传播与整合素扩散系数成正比的速度通过研磨。
In living cells, the cytoskeleton connects to the extracellular environment through focal adhesions, multimolecular structures that can sense applied force. A model is presented that for the first time explains why the focal adhesions tend to high-curvature regions at the cell periphery. It is based on experimental evidence for positive feedback between adhesion formation and assembly of actomyosin bundles (stress fibers). The model predicts that the focal adhesions propagate by treadmilling with a velocity proportional to the integrin diffusion coefficient.