HDL subclasses are heterogeneous in their associations with body fat, as measured by dual-energy X-ray absorptiometry: the Kitakata Kids Health Study
HDL subclasses are heterogeneous in their associations with body fat, as measured by dual-energy X-ray absorptiometry: the Kitakata Kids Health Study
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通过双能 X 射线吸收测定法测量，HDL 亚类与身体脂肪的关联存在异质性：喜多方儿童健康研究
DOI：
10.1016/j.cca.2015.02.011
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发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Iki M
中科院分区：
文献类型：
--
作者：
Kouda K;Nakamura H;Fujita Y;Hamada M;Kajita E;Nakatani Y;Sato Y;Uenishi K;Iki M
背景肥胖定义为体内脂肪过度堆积，常与低浓度高密度脂蛋白(HDLc)胆固醇有关。然而，高密度脂蛋白颗粒在大小和组成上是不均匀的。高密度脂蛋白亚类可能与体脂有不同的关联。方法本研究调查了用高效液相色谱法测定的高密度脂蛋白亚类的胆固醇浓度与用双能X射线吸收法测量的体脂变量之间的关系。结果共获得87名学生的体脂和血清高密度脂蛋白水平的横断面数据，占总人数的72.5%。大的高密度脂蛋白亚类的胆固醇浓度与全身脂肪和躯干脂肪呈显著的负相关(r=0.24和−=0.30)，而小高密度脂蛋白亚类的浓度与这些体脂变量呈显著的正相关(r=0.25和0.31)。在调整了潜在的混杂因素后，小高密度脂蛋白的平均浓度从躯干脂肪质量指数的最低位到最高位显著增加。结论这些结果表明，日本学生的高密度脂蛋白亚类与体脂变量的相关性具有异质性，这些变量是由双能X线吸收法准确测量的。
BackgroundObesity, defined as the excessive accumulation of body fat, is frequently associated with low concentrations of high-density lipoprotein (HDL) cholesterol. However, HDL particles are heterogeneous in size and composition. HDL subclasses may be differentially associated with body fat.MethodsThis study investigated associations between the cholesterol concentrations of HDL subclasses, as determined by high-performance liquid chromatography, and body fat variables, as measured by dual-energy X-ray absorptiometry. The source population was all ninth grade students who attended Shiokawa Junior High School in Japan.ResultsCross-sectional data on body fat and serum HDL subclasses were obtained for 87 students (72.5% of the source population). The cholesterol concentration of the large HDL subclass showed a significant (P < 0.05) inverse relationship with whole body fat and trunk fat (r = − 0.24 and − 0.30), whereas the concentration of the small HDL subclass showed a significant positive relationship with these body fat variables (r = 0.25 and 0.31). After adjusting for potential confounding factors, the mean concentration of small HDL significantly increased from the lowest to highest tertiles of trunk fat mass index.ConclusionThese results indicate that HDL subclasses are heterogeneous in their associations with body fat variables that were accurately measured by dual-energy X-ray absorptiometry among Japanese students.