Sleep characteristics and cognitive impairment in the general population The HypnoLaus study
Sleep characteristics and cognitive impairment in the general population The HypnoLaus study
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DOI：
10.1212/wnl.0000000000003557
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发表时间：
2017-01-31
期刊：
影响因子：
9.9
通讯作者：
Popp, Julius
中科院分区：
文献类型：
--
作者：
Haba-Rubio, Jose;Marti-Soler, Helena;Popp, Julius
目的：为了评估睡眠结构和认知功能障碍之间的关联，在一般population.Methods：数据源于580名参与者年龄。65年的人口为基础的CoLaus/ PsyCoLaus研究（洛桑，瑞士）谁进行了完整的睡眠评估（HypnoLaus）。评估包括人口统计学特征，个人和治疗史，睡眠投诉和习惯（使用有效的问卷调查），以及在家里进行完整的多导睡眠图。认知功能的评估使用综合神经心理测试电池和参与者的日常活动的问卷调查。认知障碍受试者（全球临床痴呆评定[CDR]量表评分。0)结果：291例有认知功能障碍的受试者（CDR总分5 0分）中，有1例有认知功能障碍，有1例无认知功能障碍。与289名CDR 5 0（72.1 +/-4.6岁）的对照组相比，CDR 0（72.5 +/- 4.6岁）的对照组有更多的浅睡眠（N1期）和更少的深睡眠（N3期）和REM睡眠，以及更低的睡眠效率，更高的内睡眠觉醒和更高的嗜睡评分（所有p，0.05）。睡眠呼吸障碍在有认知障碍的参与者中更为严重，呼吸暂停/呼吸不足指数（AHI）为18.0（7.8-35.5）/h（p50 [p25-p75]）（vs 12.9 [7.2-24.5]/h，p，0.001），氧去饱和指数（ODI）较高。在调整混杂变量后的多变量分析中，AHI和ODI >= 4%和>= 6%与认知功能障碍独立相关。结论：参与者年龄。65岁认知功能障碍有较高的嗜睡评分和更中断的睡眠。这似乎与睡眠呼吸障碍的发生和相关的间歇性缺氧有关。
Objective: To assess the association between sleep structure and cognitive impairment in the general population.Methods: Data stemmed from 580 participants aged.65 years of the population-based CoLaus/ PsyCoLaus study (Lausanne, Switzerland) who underwent complete sleep evaluation (HypnoLaus). Evaluations included demographic characteristics, personal and treatment history, sleep complaints and habits (using validated questionnaires), and a complete polysomnography at home. Cognitive function was evaluated using a comprehensive neuropsychological test battery and a questionnaire on the participant's everyday activities. Participants with cognitive impairment (global Clinical Dementia Rating [CDR] scale score. 0) were compared with participants with no cognitive impairment (global CDR score 5 0).Results: The 291 participants with a CDR score. 0 (72.5 +/- 4.6 years), compared to the 289 controls with CDR 5 0 (72.1 +/- 4.6 years), had significantly more light (stage N1) and less deep (stage N3) and REM sleep, as well as lower sleep efficiency, higher intrasleep wake, and higher sleepiness scores (all p, 0.05). Sleep-disordered breathing was more severe in participants with cognitive impairment with an apnea/hypopnea index (AHI) of 18.0 (7.8-35.5)/h (p50 [p25-p75]) (vs 12.9 [7.2-24.5]/h, p, 0.001), and higher oxygen desaturation index (ODI). In the multivariate analysis after adjustments for confounding variables, the AHI and the ODI >= 4% and >= 6% were independently associated with cognitive impairment.Conclusions: Participants aged.65 years with cognitive impairment have higher sleepiness scores and a more disrupted sleep. This seems to be related to the occurrence of sleepdisordered breathing and the associated intermittent hypoxia.