The effect of beta-aminoproprionitrile on the periodontal ligament. I. Ultrastructure of fibroblasts and matrix.
The effect of beta-aminoproprionitrile on the periodontal ligament. I. Ultrastructure of fibroblasts and matrix.
复制标题
β-氨基丙腈对牙周膜的影响。
DOI：
10.1111/j.1600-0765.1984.tb00816.x
复制
发表时间：
1984
影响因子：
3.5
通讯作者：
Garant,PR
中科院分区：
文献类型：
--
作者：
Cho,MI;Garant,PR
对幼年小鼠给予β-氨基丙腈（B-APN）会在PDL的中部区域产生特征性病变（蹄铁小体）。在这些病变内，成纤维细胞聚集形成10至20个细胞的细胞簇。聚集的成纤维细胞与胶原基质的无细胞区域相邻。单个成纤维细胞保持细胞质极性，并提供了一个很好的模型，用于研究胶原蛋白分泌从固定的成纤维细胞。胶原基质似乎被吸收的成纤维细胞簇附近。3 H-脯氨酸放射自显影表明，标记的胶原基质优先从中间区域的PDL的控制和实验小鼠。然而，B-APN处理和成纤维细胞在该区域的聚集加剧了中间区域胶原的减少。
Administration of Beta‐aminoproprionitrile (B‐APN) to young mice produced a characteristic lesion, the lathyritic body, in the middle region of the PDL. Within these lesions the fibroblasts aggregated to form cell clusters of 10 to 20 cells. The aggregated fibroblasts bordered cell‐free regions of collagenous matrix. Individual fibroblasts maintained cytoplasmic polarity and provided a good model for studying collagen secretion from immobilized fibroblasts.Collagenous matrix appeared to be resorbed in the immediate vicinity of the clustered fibroblasts.3H‐proline radioautography indicated that labelled collagenous matrix was preferentially lost from the middle region of the PDL of both control and experimental mice. However, the decrease in collagen in the middle region was accentuated by B‐APN treatment and the aggregation of fibroblasts in that zone.