Higher spermidine intake is linked to lower mortality: a prospective population-based study
Higher spermidine intake is linked to lower mortality: a prospective population-based study
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DOI：
10.1093/ajcn/nqy102
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发表时间：
2018-08-01
影响因子：
7.1
通讯作者：
Willeit, Johann
中科院分区：
文献类型：
--
作者：
Kiechl, Stefan;Pechlaner, Raimund;Willeit, Johann
背景资料：亚精胺管理与增加生存在几个动物models.Objective：本研究的目的是测试亚精胺含量在饮食和死亡率之间的潜在关联在human.Design：这个前瞻性的社区为基础的队列研究包括829名参与者年龄在45-84岁，其中49.9%是男性。1995年、2000年、2005年和2010年，通过营养师重复管理的经验证的食物频率问卷（2540次评估）对饮食进行了评估。在1995年至2015年的随访期间，发生了341例死亡。（每1000人年死亡人数）在亚精胺摄入量增加的三分之一之间从40.5（95% CI：36.1，44.7）至23.7（95% CI：20.0，27.0）和15.1（95%CI：12.6，17.8），相当于年龄、性别和热量摄入调整后的20年累积死亡率为0.48（95% CI：0.45，0.51）、0.41（95% CI：0.38，0.45）和0.38（95% CI：0.34，0.41）。每增加1个标准差的亚精胺摄入量，经年龄、性别和热量比校正的全因死亡HR为0.74（95% CI：0.66，0.83; P < 0.001）。进一步调整生活方式因素、已建立的死亡率预测因子和其他饮食特征后，HR为0.76（95%CI：0.67，0.86; P < 0.001）。这种关联在亚组中是一致的，对于未测量的混杂因素是稳健的，并且在高个体风险受试者的萨尔茨堡动脉粥样硬化预防计划（SAPHIR）研究中得到独立验证（年龄、性别和热量比调整的每1-SD高亚精胺摄入量的HR：0.71; 95% CI：0.53，0.95; P = 0.019）。亚精胺摄入量的顶部和底部三分之一之间的死亡风险的差异是类似的，与一个5.7-Y（95% CI：3.6，8.1 Y）年轻的age.Conclusion：我们的研究结果提供流行病学支持的概念，即营养丰富的亚精胺与人类生存率增加。
Background: Spermidine administration is linked to increased survival in several animal models.Objective: The aim of this study was to test the potential association between spermidine content in diet and mortality in humans.Design: This prospective community-based cohort study included 829 participants aged 45-84 y, 49.9% of whom were male. Diet was assessed by repeated dietitian-administered validated food-frequency questionnaires (2540 assessments) in 1995, 2000, 2005, and 2010. During follow-up between 1995 and 2015, 341 deaths occurred.Results: All-cause mortality (deaths per 1000 person-years) decreased across thirds of increasing spermidine intake from 40.5 (95% CI: 36.1, 44.7) to 23.7 (95% CI: 20.0, 27.0) and 15.1 (95% CI: 12.6, 17.8), corresponding to an age-, sex-and caloric intake-adjusted 20-y cumulative mortality incidence of 0.48 (95% CI: 0.45, 0.51), 0.41 (95% CI: 0.38, 0.45), and 0.38 (95% CI: 0.34, 0.41), respectively. The age-, sex-and caloric ratio-adjusted HR for all-cause death per 1-SD higher spermidine intake was 0.74 (95% CI: 0.66, 0.83; P < 0.001). Further adjustment for lifestyle factors, established predictors of mortality, and other dietary features yielded an HR of 0.76 (95% CI: 0.67, 0.86; P < 0.001). The association was consistent in subgroups, robust against unmeasured confounding, and independently validated in the Salzburg Atherosclerosis Prevention Program in Subjects at High Individual Risk (SAPHIR) Study (age-, sex-, and caloric ratioadjusted HR per 1-SD higher spermidine intake: 0.71; 95% CI: 0.53, 0.95; P = 0.019). The difference in mortality risk between the top and bottom third of spermidine intakes was similar to that associated with a 5.7-y (95% CI: 3.6, 8.1 y) younger age.Conclusion: Our findings lend epidemiologic support to the concept that nutrition rich in spermidine is linked to increased survival in humans.