Intellectual and developmental disability and COVID-19 case-fatality trends: TriNetX analysis
Intellectual and developmental disability and COVID-19 case-fatality trends: TriNetX analysis
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DOI：
10.1016/j.dhjo.2020.100942
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发表时间：
2020-07-01
影响因子：
4.5
通讯作者：
Goss, Katherine D.
中科院分区：
文献类型：
--
作者：
Turk, Margaret A.;Landes, Scott D.;Goss, Katherine D.
背景：尽管在智力与发育障碍人群中，新冠肺炎导致严重后果的风险可能更高，但关于这一人群的新冠肺炎趋势的报道有限。目的：比较智力与发育障碍人群中新冠肺炎的总体趋势和按年龄分层的趋势。方法：使用TriNetX新冠肺炎研究网络平台的数据来识别新冠肺炎患者。重点分析了截至2020年5月14日，新冠肺炎诊断为阳性的IDD患者和非IDD患者的合并症、病例数、死亡人数和病例率的趋势。结果：IDD患者的特定合并症患病率较高，与COVID19预后较差相关。在碘缺乏病患者中，新冠肺炎的趋势在年龄上存在明显的差异，新冠肺炎病例在较年轻时更集中。此外，尽管IDD患者的总体发病率(5.1%)与非IDD患者(5.4%)相似，但这些比率因年龄而不同：
Background: Despite possibly higher risk of severe outcomes from COVID-19 among people with intellectual and developmental disabilities (IDD), there has been limited reporting of COVID-19 trends for this population.Objective: To compare COVID-19 trends among people with and without IDD, overall and stratified by age.Methods: Data from the TriNetX COVID-19 Research Network platform was used to identify COVID-19 patients. Analysis focused on trends in comorbidities, number of cases, number of deaths, and casefatality rate among patients with and without IDD who had a positive diagnosis for COVID- 19 through May 14, 2020.Results: People with IDD had higher prevalence of specific comorbidities associated with poorer COVID19 outcomes. Distinct age-related differences in COVID-19 trends were present among those with IDD, with a higher concentration of COVID-19 cases at younger ages. In addition, while the overall casefatality rate was similar for those with IDD (5.1%) and without IDD (5.4%), these rates differed by age: ages