Rapidly light-activated surgical protein glue inspired by mussel adhesion and insect structural crosslinking
Rapidly light-activated surgical protein glue inspired by mussel adhesion and insect structural crosslinking
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DOI：
10.1016/j.biomaterials.2015.07.014
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发表时间：
2015-10-01
期刊：
影响因子：
14
通讯作者：
Cha, Hyung Joon
中科院分区：
文献类型：
--
作者：
Jeon, Eun Young;Hwang, Byeong Hee;Cha, Hyung Joon
目前批准的手术组织胶由于在潮湿条件下的粘附有限和严重的细胞毒性而不满足理想生物粘合剂的要求。在此，我们报道了一种新的光激活的贻贝蛋白生物粘合剂（LAMBA），其灵感来自于贻贝粘附和昆虫二酪氨酸交联化学。在体外和体内研究中，LAMBA表现出比市售纤维蛋白胶更强的大块湿组织粘附性和良好的生物相容性。此外，易于调节的光激活交联能够有效地按需缝合伤口，促进伤口愈合。基于这些杰出的特性，LAMBA作为一种理想的外科组织胶具有巨大的潜力，可用于各种医疗应用，包括皮肤和内脏器官的无缝合线伤口闭合。(C) 2015 Elsevier Ltd.版权所有。
Currently approved surgical tissue glues do not satisfy the requirements for ideal bioadhesives due to limited adhesion in wet conditions and severe cytotoxicity. Herein, we report a new light-activated, mussel protein-based bioadhesive (LAMBA) inspired by mussel adhesion and insect dityrosine cross-linking chemistry. LAMBA exhibited substantially stronger bulk wet tissue adhesion than commercially available fibrin glue and good biocompatibility in both in vitro and in vivo studies. Besides, the easily tunable, light-activated crosslinking enabled an effective on-demand wound closure and facilitated wound healing. Based on these outstanding properties, LAMBA holds great potential as an ideal surgical tissue glue for diverse medical applications, including sutureless wound closures of skin and internal organs. (C) 2015 Elsevier Ltd. All rights reserved.