A TRANSIENT MATHEMATICAL-MODEL OF OXYGEN DEPLETION DURING PHOTODYNAMIC THERAPY
A TRANSIENT MATHEMATICAL-MODEL OF OXYGEN DEPLETION DURING PHOTODYNAMIC THERAPY
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DOI：
10.2307/3579032
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发表时间：
1995-05-01
影响因子：
3.4
通讯作者：
HAMPTON, JA
中科院分区：
文献类型：
--
作者：
HENNING, JP;FOURNIER, RL;HAMPTON, JA
提出了一个瞬态一维数学模型，以帮助可视化的定性和定量的影响毛细血管间组织进行光动力学治疗（PDT）。该模型通过Crank-Nicholson有限差分公式求解，以提供毛细血管周围组织中II型机制的光氧化物质的时间依赖性浓度。时间依赖性解决方案允许对光分离（开/关）循环的最佳定时做出有根据的决定，PDT过程的定性和定量优化被认为是沿着文献中数据的案例研究，主要目标是为最终的临床应用提供优化的光治疗方案。(C)1995年，辐射研究学会
A transient one-dimensional mathematical model is presented to help visualize the qualitative and quantitative effects on intercapillary tissue undergoing photodynamic therapy (PDT). The model is solved by a Crank-Nicholson finite difference formulation to provide time-dependent concentrations of the Type II mechanism's photo-oxidation species in the tissue surrounding a capillary, The time-dependent solution allows educated decisions to be made as to the optimum timing of light fractionation (on/off) cycles, Qualitative and quantitative optimization of the PDT process is considered along with a case study of data in the literature, the main goal being to provide optimized light therapy regimens for eventual clinical use. (C) 1995 by Radiation Research Society