Polyamines: Mysterious modulators of cellular functions
Polyamines: Mysterious modulators of cellular functions
复制标题
DOI：
10.1006/bbrc.2000.2601
复制
发表时间：
2000-05-19
影响因子：
3.1
通讯作者：
Kashiwagi, K
中科院分区：
文献类型：
--
作者：
Igarashi, K;Kashiwagi, K
近年来，多胺（腐胺，亚精胺和精胺）的功能已在分子水平上进行了研究。多胺可以调节RNA、DNA、核苷酸三磷酸、蛋白质和其他酸性物质的功能。多胺的细胞功能的主要部分可以通过RNA的结构变化来解释，该结构变化在生理浓度的Mg 2+和K+下发生，因为大多数多胺存在于细胞内的多胺-RNA复合物中。发现多胺在几个不同的水平上调节蛋白质合成，包括刺激特殊类型的蛋白质合成，刺激30 S核糖体亚基的组装和刺激Ile-tRNA的形成。多胺对离子通道的影响也有报道，并逐渐在分子水平上得到澄清。(C)北京大学出版社.
In recent years the functions of polyamines (putrescine, spermidine, and spermine) have been studied at the molecular level. Polyamines can modulate the functions of RNA, DNA, nucleotide triphosphates, proteins, and other acidic substances. A major part of the cellular functions of polyamines can be explained through a structural change of RNA which occurs at physiological concentrations of Mg2+ and K+ because most polyamines exist in a polyamine-RNA complex within cells. Polyamines were found to modulate protein synthesis at several different levels including stimulation of special kinds of protein synthesis, stimulation of the assembly of 30 S ribosomal subunits and stimulation of Ile-tRNA formation. Effects of polyamines on ion channels have also been reported and are gradually being clarified at the molecular level. (C) 2000 Academic Press.