Innate Regeneration in the Aging Heart: Healing From Within
Innate Regeneration in the Aging Heart: Healing From Within
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DOI：
10.1016/j.mayocp.2013.04.001
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发表时间：
2013-08-01
影响因子：
8.9
通讯作者：
Leri, Annarosa
中科院分区：
文献类型：
--
作者：
Anversa, Piero;Leri, Annarosa
心脏作为一种无法替代受损心肌细胞的终末分化器官的概念在过去 50 年中一直是心血管研究和治疗开发的中心。心肌细胞数量随着年龄的增长而逐渐减少，以及心肌梗塞后疤痕组织的形成，已被解释为心脏有丝分裂后特征无可辩驳的证据。然而，新出现的证据支持对心脏更加动态的看法，其中细胞死亡和更新是控制心脏稳态、衰老和疾病的重塑过程的重要组成部分。成人和衰老心脏中分裂肌细胞的鉴定提出了有关这些新形成细胞起源的重要问题。体外和体内研究结果强烈表明，复制的心肌细胞源自常驻原始细胞的谱系决定，支持心肌发生是由干细胞区室的激活和分化控制的观点。目前的观点认为，心肌是允许由外源性和内源性祖细胞介导的组织再生的器官。 (C)(C) 2013 梅奥医学教育与研究基金会
The concept of the heart as a terminally differentiated organ incapable of replacing damaged myocytes has been at the center of cardiovascular research and therapeutic development for the past 50 years. The progressive decline in myocyte number as a function of age and the formation of scarred tissue after myocardial infarction have been interpreted as irrefutable proofs of the postmitotic characteristic of the heart. However, emerging evidence supports a more dynamic view of the heart in which cell death and renewal are vital components of the remodeling process that governs cardiac homeostasis, aging, and disease. The identification of dividing myocytes in the adult and senescent heart raises the important question concerning the origin of these newly formed cells. In vitro and in vivo findings strongly suggest that replicating myocytes derive from lineage determination of resident primitive cells, supporting the notion that cardiomyogenesis is controlled by activation and differentiation of a stem cell compartment. It is the current view that the myocardium is an organ permissive of tissue regeneration mediated by exogenous and endogenous progenitor cells. (C)(C) 2013 Mayo Foundation for Medical Education and Research