Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine
Initial report of decreased SARS-CoV-2 viral load after inoculation with the BNT162b2 vaccine
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DOI：
10.1038/s41591-021-01316-7
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发表时间：
2021-03-29
期刊：
影响因子：
82.9
通讯作者：
Kishony, Roy
中科院分区：
文献类型：
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作者：
Levine-Tiefenbrun, Matan;Yelin, Idan;Kishony, Roy
除了对个体接种者的实质性保护外，2019冠状病毒病（COVID-19）疫苗可能会减少突破性感染的病毒载量，从而进一步抑制进一步传播。在对接种BNT 162 b2信使RNA疫苗后严重急性呼吸综合征冠状病毒2型（SARS-CoV-2）阳性检测结果的真实数据集进行分析时，我们发现，在首次接种疫苗后12-37天发生的感染中，病毒载量大幅降低。这些降低的病毒载量暗示了潜在的较低感染性，进一步促进了疫苗对病毒传播的影响。在首次接种BNT 162 b2 mRNA疫苗后12天或更长时间发生的SARS-CoV-2突破性感染与未接种疫苗的个体中发现的较低病毒载量相关，这表明疫苗可能降低感染性。
Beyond their substantial protection of individual vaccinees, coronavirus disease 2019 (COVID-19) vaccines might reduce viral load in breakthrough infection and thereby further suppress onward transmission. In this analysis of a real-world dataset of positive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) test results after inoculation with the BNT162b2 messenger RNA vaccine, we found that the viral load was substantially reduced for infections occurring 12-37 d after the first dose of vaccine. These reduced viral loads hint at a potentially lower infectiousness, further contributing to vaccine effect on virus spread.Breakthrough infections of SARS-CoV-2 occurring 12 or more days after the first dose of the BNT162b2 mRNA vaccine were associated with lower viral loads than those found in unvaccinated individuals, suggesting that the vaccine might reduce infectiousness.