Sniff magnitude test: relationship to odor identification, detection, and memory tests in a clinic population.
Sniff magnitude test: relationship to odor identification, detection, and memory tests in a clinic population.
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DOI：
10.1093/chemse/bjm020
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发表时间：
2007-07
期刊：
影响因子：
3.5
通讯作者：
Isabelle A Tourbier;R. Doty
中科院分区：
文献类型：
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作者：
Isabelle A Tourbier;R. Doty
最近开发了一种新的嗅觉功能测量方法，嗅觉强度测试(SMT)，它依赖于吸入对气味的反应的变化。这种独特的测试与其他嗅觉测试的关系几乎没有得到调查。在这项研究中，我们评估了132名到化学感觉障碍诊所就诊的患者的SMT分数与3项标准化心理物理测试的关系：宾夕法尼亚大学气味识别测试(UPSIT)、苯乙醇气味检测阈值测试和短期气味记忆/辨别测试。SMT评分大致与为UPSIT定义的嗅觉障碍类别相关，与其他测试的相关性中等。恶臭物质(1%和3%甲硫基丁酸酯[MTB]，1%3-巯基己酸乙酯)比非恶臭物质(3%苯乙醇[PEA]、3%乙酸戊酯、3%正丁醇)具有更强的相关性，并引起更大的嗅觉抑制。在主成分分析中，SMT测量加载在不同于其他测试的加载在单独组件上的组件上。对于遇到的第一种恶臭(1%MTB)，但对于第一种非恶臭(3%PEA)，预期反应(即，较小的嗅觉)在试验中发生。这些结果，以及早期的因素分析，表明嗅觉的大小受到气味质量和强度的影响，以及认知因素的影响。
Recently a novel measure of olfactory function, the Sniff Magnitude Test (SMT), was developed that relies on changes in inhalation in response to an odor. The relationship of this unique test to that of other olfactory tests has received little investigation. In this study, we assessed, in 132 patients presenting to a chemosensory disorders clinic, the relationship of SMT scores to those from 3 standardized psychophysical tests: the University of Pennsylvania Smell Identification Test (UPSIT), a phenyl ethyl alcohol odor detection threshold test, and a short-term odor memory/discrimination test. SMT scores were roughly related to olfactory dysfunction categories defined for the UPSIT and correlated moderately with the other tests. Malodors (1% and 3% methylthiobutyrate [MTB], 1% ethyl 3-mercaptoproprionate) exhibited stronger correlations than nonmalodors (3% phenyl ethyl alcohol [PEA], 3% amyl acetate, 3% n-butanol) and elicited greater sniff suppression. In a principal component analysis, the SMT measures loaded on components different from those of the other tests, which loaded on a separate component. Anticipatory responses (i.e., smaller sniffs) occurred across trials for the first malodor (1% MTB), but not for the first nonmalodor (3% PEA), that was encountered. These results, along with those of an earlier factor analysis, suggest that sniff magnitude is influenced by odorant quality and intensity, as well as by cognitive factors.