Immune-mediated Liver Injury in Hepatitis B Virus Infection.
Immune-mediated Liver Injury in Hepatitis B Virus Infection.
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DOI：
10.4110/in.2015.15.4.191
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发表时间：
2015-08
期刊：
影响因子：
6
通讯作者：
Park SH
中科院分区：
文献类型：
--
作者：
Oh IS;Park SH
乙型肝炎病毒 (HBV) 导致全球约 3.5 亿人慢性感染，是导致肝炎、肝硬化和肝癌等广谱肝病的主要原因。尽管人们已经明确适应性免疫在病毒清除中发挥着关键作用，但急性和慢性乙型肝炎病毒感染期间导致肝损伤的发病机制仍然广为人知。这篇综述描述了我们目前对 HBV 感染的免疫介导发病机制以及免疫细胞在乙型肝炎肝损伤中的作用的了解。
Hepatitis B virus (HBV) is responsible for approximately 350 million chronic infections worldwide and is a leading cause of broad-spectrum liver diseases such as hepatitis, cirrhosis and liver cancer. Although it has been well established that adaptive immunity plays a critical role in viral clearance, the pathogenetic mechanisms that cause liver damage during acute and chronic HBV infection remain largely known. This review describes our current knowledge of the immune-mediated pathogenesis of HBV infection and the role of immune cells in the liver injury during hepatitis B.