Sevoflurane impairs post-operative olfactory memory but preserves olfactory function
Sevoflurane impairs post-operative olfactory memory but preserves olfactory function
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DOI：
10.1097/eja.0b013e328340702b
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发表时间：
2011-01-01
影响因子：
3.6
通讯作者：
Papageorgiou, Charalambos
中科院分区：
文献类型：
--
作者：
Kostopanagiotou, Georgia;Kalimeris, Konstantinos;Papageorgiou, Charalambos
背景与目的麻醉对嗅觉功能的影响尚未有系统的研究。我们的目的是比较全身麻醉和区域麻醉对嗅觉敏锐度和记忆力的影响，在术后立即periods.Methods 60例成人患者与美国麻醉医师协会I和II的状态安排择期小手术。排除标准为吸烟、酗酒、精神疾病和近期或既往呼吸道感染导致的嗅觉减退。患者被随机分配到三组中的一组（在分析中，每组n = 16）：硬膜外麻醉（E组），丙泊酚全身麻醉（P组）和七氟烷全身麻醉（S组），持续时间为40-120分钟。在手术前的晚上，在手术后0.5和3小时，测试嗅觉敏锐度和记忆力，沿着进行血液采样以测量血浆褪黑激素和催产素水平。嗅觉敏锐度进行了测试，连续稀释的正丁醇，嗅觉记忆（气味的解释）与宾夕法尼亚大学的气味识别Test.Results患者的特点没有组间差异。麻醉前后，所有患者的嗅觉敏锐度均完好无损。与P组和E组相比，S组在术后两个时间点的嗅觉记忆恶化。这伴随着S组中血浆褪黑激素水平的术后显著降低。催产素水平保持不变，在所有groups.Conclusion我们的研究结果表明，七氟醚对嗅觉记忆的具体影响，没有观察到与轴索或全静脉麻醉。七氟烷在术后即刻对气味的误解可能由褪黑激素水平降低介导。Eur J Anaesthesiol 2011;28：63-68 2010年10月19日在线发表
Background and objective The effect of anaesthesia on olfaction has not been systematically studied. Our aim is to compare the effects of general and regional anaesthesia on olfactory acuity and memory in the immediate post-operative period.Methods Sixty adult patients with the American Society of Anesthesiologists I and II status scheduled for elective minor surgery were included. Exclusion criteria were smoking, alcoholism, psychiatric disease and recent or past airway infection with resulting hyposmia. Patients were randomly allocated to one of three groups (in the analysis, n = 16 in each group): epidural anaesthesia (group E), general anaesthesia with propofol (group P) and general anaesthesia with sevoflurane (group S) of 40-120 min duration. The evening before surgery, at 0.5 and at 3 h post-operatively olfactory acuity and memory were tested, along with blood sampling to measure plasma melatonin and oxytocin levels. Olfactory acuity was tested with successive dilutions of n-butyl-alcohol, and olfactory memory (interpretation of odours) with the University of Pennsylvania Smell Identification Test.Results Patient characteristics did not differ between groups. Olfactory acuity was intact in all patients, before and after anaesthesia. Olfactory memory deteriorated in group S compared to groups P and E at both post-operative time-points. This was accompanied by a significant post-operative reduction of plasma melatonin levels in group S. Oxytocin levels remained constant in all groups.Conclusion Our results manifest a specific effect of sevoflurane on olfactory memory, not observed with neuraxial or total intravenous anaesthesia. The misinterpretation of odours in the immediate post-operative period by sevoflurane could be mediated by the decreased levels of melatonin. Eur J Anaesthesiol 2011;28:63-68 Published online 19 October 2010