The effect of collagen fibril orientation on the biphasic mechanics of articular cartilage
The effect of collagen fibril orientation on the biphasic mechanics of articular cartilage
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DOI：
10.1016/j.jmbbm.2016.09.001
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发表时间：
2017-01-01
影响因子：
3.9
通讯作者：
Jones, Alison
中科院分区：
文献类型：
--
作者：
Meng, Qingen;An, Shuqiang;Jones, Alison
胶原纤维的高度不均匀分布可能对关节软骨的双相力学有重要影响。然而，目前主要使用简化的三层模型来研究胶原纤维的不均一性的影响，这可能低估了胶原纤维的影响，忽略了它们的真实取向。本研究的目的是探讨胶原纤维的真实取向对关节软骨双相力学的影响。使用两个不同的有限元软件(ABAQUS和FEBio)求解了五个两相材料模型，每个模型包括不同程度的纤维增强。模型I考虑了纤维的真实取向，这是从扩散张量磁共振图像得出的。模型2采用简化的三层定向，模型3-5为三个对照模型。本研究得到的胶原蛋白的真实取向与文献相符。对于所模拟的每个条件，两种有限元实施的结果是一致的。对照模型的比较证实了胶原纤维的某些功能。模型1和模型2的比较表明，广泛使用的三层非均质模型可以产生与模型相似的流体负荷支持，包括真实的纤维取向；然而，其他力学参数的准确预测需要包含胶原纤维的真实取向。(C)2016年提交人。由爱思唯尔有限公司出版。这是一篇在CC许可下的开放获取文章。
The highly inhomogeneous distribution of collagen fibrils may have important effects on the biphasic mechanics of articular cartilage. However, the effect of the inhomogeneity of collagen fibrils has mainly been investigated using simplified three-layered models, which may have underestimated the effect of collagen fibrils by neglecting their realistic orientation. The aim of this study was to investigate the effect of the realistic orientation of collagen fibrils on the biphasic mechanics of articular cartilage. Five biphasic material models, each of which included a different level of complexity of fibril reinforcement, were solved using two different finite element software packages (Abaqus and FEBio). Model I considered the realistic orientation of fibrils, which was derived from diffusion tensor magnetic resonance images. The simplified three-layered orientation was used for Model 2. Models 3-5 were three control models. The realistic collagen orientations obtained in this study were consistent with the literature. Results from the two finite element implementations were in agreement for each of the conditions modelled. The comparison between the control models confirmed some functions of collagen fibrils. The comparison between Models 1 and 2 showed that the widely-used three-layered inhomogeneous model can produce similar fluid load support to the model including the realistic fibril orientation; however, an accurate prediction of the other mechanical parameters requires the inclusion of the realistic orientation of collagen fibrils. (C) 2016 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY license.