Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition.
Quassinoid inhibition of AP-1 function does not correlate with cytotoxicity or protein synthesis inhibition.
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DOI：
10.1021/np800732n
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发表时间：
2009-03-27
影响因子：
5.1
通讯作者：
Henrich, Curtis J.
中科院分区：
文献类型：
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作者：
Beutler, John A.;Kang, Moon-Il;Robert, Francis;Clement, Jason A.;Pelletier, Jerry;Colburn, Nancy H.;McKee, Tawnya C.;Goncharova, Ekaterina;McMahon, James B.;Henrich, Curtis J.
在高通量筛选测定中鉴定了几种苦木素类化合物作为转录因子AP-1的抑制剂。进一步的生物学表征表明，虽然它们的作用不是AP-1特异性的，但蛋白质合成抑制和细胞生长测定与简单的蛋白质合成抑制机制不一致。在相同的筛选中还鉴定了来自植物科Simaroubaceae的许多植物提取物;一种提取物（Ailanthus triphylla）的生物测定引导的分级分离产生了两种已知的苦木素，椿皮酮（3）和蓝胭脂酮（4），其也在纯化合物筛选程序中鉴定。
Several quassinoids were identified in a high-throughput screening assay as inhibitors of the transcription factor AP-1. Further biological characterization revealed that while their effect was not specific to AP-1, protein synthesis inhibition and cell growth assays were inconsistent with a mechanism of simple protein synthesis inhibition. Numerous plant extracts from the plant family Simaroubaceae were also identified in the same screen; bioassay-guided fractionation of one extract (Ailanthus triphylla) yielded two known quassinoids, ailanthinone (3) and glaucarubinone (4), which were also identified in the pure compound screening procedure.
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影响因子：
10.4
作者：
Suzukawa K;Weber TJ;Colburn NH
通讯作者：
Colburn NH
影响因子：
1.8
作者：
MORETTI, C;POLONSKY, J;PRANGE, T
通讯作者：
PRANGE, T
影响因子：
--
作者：
Ruocco, Katie M.;Goncharova, Ekaterina I.;Henrich, Curtis J.
通讯作者：
Henrich, Curtis J.
影响因子：
3.8
作者：
GAUDEMER, ALAIN;POLONSKY, JUDITH
通讯作者：
POLONSKY, JUDITH
影响因子：
11.5
作者：
Cuendet, M;Christov, K;Pezzuto, JM
通讯作者：
Pezzuto, JM