Evaluation of potential environmental toxicity of polymeric nanomaterials and surfactants
Evaluation of potential environmental toxicity of polymeric nanomaterials and surfactants
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DOI：
10.1016/j.etap.2020.103353
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发表时间：
2020-05-01
影响因子：
4.3
通讯作者：
Wacker, Matthias G.
中科院分区：
文献类型：
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作者：
Hering, Indra;Eilebrecht, Elke;Wacker, Matthias G.
纳米材料在包括纳米医学在内的各个领域都获得了巨大的重要性。药物和纳米载体的纳米制剂用于提高药效。然而，人们发现聚合物纳米材料会产生负面影响。因此，有必要确定对水生生物不利影响最小的纳米材料。为了确定聚合物纳米材料的毒性，我们使用鱼胚胎毒性测试 (FET) 研究了聚乳酸-乙交酯酸 (PLGA)、Eudragit (R) E 100 和羟丙基甲基纤维素邻苯二甲酸酯 (HPMCP) 对斑马鱼胚胎的影响。此外，我们研究了用于纳米制剂生成的 Cremophor (R) RH40、Cremophor (R) A25、Pluronic (R) F127 和 Pluronic (R) F68，以确定毒性影响最小的表面活性剂。生态毒性顺序为 HPMCP < PLGA < Eudragit (R) E100 和 Pluronic (R) F68 < Pluronic (R) F127 < Cremophor (R) RH40 < Cremophor (R) A25。总之，HPMCP 和 Pluronic (R) F68 显示出最小的毒性影响，因此表明纳米药物的生产具有足够的环境相容性。
Nanomaterials have gained huge importance in various fields including nanomedicine. Nanoformulations of drugs and nanocarriers are used to increase pharmaceutical potency. However, it was seen that polymeric nanomaterials can cause negative effects. Thus, it is essential to identify nanomaterials with the least adverse effects on aquatic organisms. To determine the toxicity of polymeric nanomaterials, we investigated the effects of poly(lactic-co-glycolid) acid (PLGA), Eudragit (R) E 100 and hydroxylpropyl methylcellulose phthalate (HPMCP) on zebrafish embryos using the fish embryo toxicity test (FET). Furthermore, we studied Cremophor (R) RH40, Cremophor (R) A25, Pluronic (R) F127 and Pluronic (R) F68 applied in the generation of nanoformulations to identify the surfactant with minimal toxic impact. The order of ecotoxicty was HPMCP < PLGA < Eudragit (R) E100 and Pluronic (R) F68 < Pluronic (R) F127 < Cremophor (R) RH40 < Cremophor (R) A25. In summary, HPMCP and Pluronic (R) F68 displayed the least toxic impact, thus suggesting adequate environmental compatibility for the generation of nanomedicines.