Cytoplasmic and Nuclear Estradiol Receptor in the Corpus Luteum of the Pseudopregnant Rabbit
Cytoplasmic and Nuclear Estradiol Receptor in the Corpus Luteum of the Pseudopregnant Rabbit
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假孕兔黄体细胞质和细胞核雌二醇受体
DOI：
10.3181/00379727-162-40672
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发表时间：
1979
影响因子：
--
通讯作者：
T. Mills
中科院分区：
文献类型：
--
作者：
T. Mills
摘要 在假妊娠第 2、4 和 6 天测量了兔黄体中的雌二醇结合活性。结果显示，第4天受体活性明显高于第2天，第6天继续增加。此外，注射100μg雌二醇后30分钟内，雌二醇受体活性转移到细胞核中。在假妊娠第 2、4 和 6 天注射雌二醇后，观察到明显的受体易位。结论是，兔黄体中的雌二醇结合活性归因于真正的雌二醇受体，并且该活性在假妊娠的第 4 天出现显着增加。
Summary Estradiol binding activity has been measured in the rabbit corpus luteum on Days 2, 4, and 6 of pseudopregnancy. The results show that receptor activity is significantly greater on Day 4 than on Day 2 with continued increases on Day 6. In addition, the estradiol receptor activity is translocated into the nucleus within 30 min of injection of 100 μg of estradiol. Appreciable receptor translocation is observed following estradiol injection on Days 2, 4, and 6 of pseudopregnancy. It is concluded that estradiol binding activity in the rabbit corpus luteum is due to an authentic estradiol receptor and that a marked increase in this activity occurs by the 4th day of pseudopregnancy.