Effect of repeated whole blood donations on serum immunoreactive erythropoietin levels in autologous donors.
Effect of repeated whole blood donations on serum immunoreactive erythropoietin levels in autologous donors.
复制标题
重复全血捐献对自体捐献者血清免疫反应性促红细胞生成素水平的影响。
DOI：
10.1001/jama.1988.03410010073038
复制
发表时间：
1988
期刊：
影响因子：
--
通讯作者：
J. Spivak
中科院分区：
文献类型：
--
作者：
T. Kickler;J. Spivak
对69例自体献血者反复采血对血清免疫反应性促红细胞生成素水平的影响进行了前瞻性研究。在初次放血时，11名男性（33%）和2名女性（6%）贫血；在献血过程中，另有17名男性（71%）和14名女性（45%）出现贫血（定义为男性红细胞比容低于0.41，女性红细胞比容低于0.36）。虽然连续抽血后血清免疫反应性促红细胞生成素水平有所升高，但升高幅度并不明显超出正常范围。反复抽血后红细胞生成反应的缺乏与血清促红细胞生成素水平的小增加有关，这不是由于缺铁，因为这些患者的游离红细胞原卟啉水平没有增加。我们的结论是，在允许自体献血的红细胞压积范围内，经历的贫血程度不足以启动红细胞生成素产生的适当增加；结果，大多数献血者出现轻度贫血，捐献的血量不足以满足他们的手术需要。
The effect of repeated phlebotomy on serum immunoreactive erythropoietin levels was studied prospectively in 69 autologous blood donors. At the time of the initial phlebotomy, 11 men (33%) and two women (6%) were anemic; during the course of blood donations, anemia (defined as a hematocrit less than 0.41 for men and less than 0.36 for women) developed in an additional 17 men (71%) and 14 women (45%). Although there was an increase in the level of serum immunoreactive erythropoietin with successive phlebotomies, the increase was not substantially out of the normal range. The lack of an erythropoietic response to repeated phlebotomies in association with the small increment in the serum erythropoietin level was not due to iron deficiency, since the level of red-cell free protoporphyrin did not increase in these patients. We conclude that within the hematocrit range permissible for autologous blood donation, the degree of anemia experienced is insufficient to initiate an adequate increase in erythropoietin production; as a consequence, mild anemia develops in a majority of donors, and the volume of blood donated is inadequate to meet their operative needs.
促红细胞生成素的放射免疫测定：正常人体和造血障碍患者的血清水平。
DOI：
--
发表时间：
1982
期刊：
The Journal of laboratory and clinical medicine
影响因子：
--
作者：
Rege,AB;Brookins,J;Fisher,JW
通讯作者：
Fisher,JW
DOI：
10.1056/nejm198702263160906
发表时间：
1987
期刊：
The New England journal of medicine
影响因子：
--
作者：
Toy,PT;Strauss,RG;Stehling,LC;Sears,R;Price,TH;Rossi,EC;Collins,ML;Crowley,JP;Eisenstaedt,RS;Goodnough,LT
通讯作者：
Goodnough,LT
影响因子：
158.5
作者：
ESCHBACH, JW;EGRIE, JC;ADAMSON, JW
通讯作者：
ADAMSON, JW