A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1
复制标题
DOI：
10.1038/ng1954
复制
发表时间：
2007-02-01
期刊：
影响因子：
30.8
通讯作者：
Schreiber, Stefan
中科院分区：
文献类型：
--
作者：
Hampe, Jochen;Franke, Andre;Schreiber, Stefan
我们在735名克罗恩病和368个对照组中对19,779个非同义SNP进行了全基因组关联研究。这些SNP中共有7,159个信息丰富。我们跟进了所有72个SNP，p 0.4），这些数据表明，潜在的生物过程可能是克罗恩病的特异性。
We performed a genome-wide association study of 19,779 nonsynonymous SNPs in 735 individuals with Crohn disease and 368 controls. A total of 7,159 of these SNPs were informative. We followed up on all 72 SNPs with P 0.4), these data suggest that the underlying biological process may be specific to Crohn disease.