Genomic imprinting: theories and data.
Genomic imprinting: theories and data.
复制标题
基因组印记：理论和数据。
DOI：
10.1038/hdy.2014.52
复制
发表时间：
2014
期刊：
影响因子：
3.8
通讯作者：
Spencer HG
中科院分区：
文献类型：
--
作者：
Spencer HG
如果我可以给初学者一个忠告的话，那就是：珍惜你的例外！y保持无遮盖及在视线范围内。它们就像一座正在生长的建筑物的粗糙的砖墙，告诉人们还有更多的东西要来，并显示下一个建筑物在哪里。（Bateson，1908）这个建议在干预的世纪中结出了许多果实，导致遗传学的许多基本方面的发现，包括连锁，基因相互作用和性染色体。在过去的二十年里，我们已经开始发现一个特别丰富的来源，这种贝特森例外的标准孟德尔表达形式的表观遗传遗传，如基因组印记。
If I may throw out a word of counsel to beginners, it is: Treasure your exceptions! y Keep them always uncovered and in sight. Exceptions are like the rough brickwork of a growing building which tells that there is more to come and shows where the next construction is to be.(Bateson, 1908)This advice has borne much fruit in the intervening century, leading to the discovery of numerous fundamental aspects of genetics, including linkage, gene interactions and sex chromosomes. In the last two decades, we have begun to uncover a particularly rich source of such Batesonian exceptions to standard Mendelian expression resulting from forms of epigenetic inheritance such as genomic imprinting.