Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant
Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant
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DOI：
10.1007/bf00187257
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发表时间：
2004
影响因子：
3.4
通讯作者：
P. Willner;A. Towell;D. Sampson;S. Sophokleous;R. Muscat
中科院分区：
文献类型：
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作者：
P. Willner;A. Towell;D. Sampson;S. Sophokleous;R. Muscat
长期（5-9周）暴露于各种轻度不可预测的应激源的大鼠显示出对糖精或蔗糖溶液的消耗减少和偏好。偏好缺陷需要至少2周的发展，并保持超过2周后终止的压力制度。蔗糖偏好不受三环类抗抑郁药治疗1周的影响，但在治疗2-4周后恢复正常。在无压力的动物中，蔗糖没有改变蔗糖偏好。无论是在应激过程中还是在药物治疗后，生理盐水偏好都没有显著变化。维生素D降低了血液皮质酮和葡萄糖水平，但压力并没有显着改变这两项措施。内源性抑郁症的动物模型的结果进行了讨论。
Rats exposed chronically (5–9 weeks) to a variety of mild unpredictable stressors showed a reduced consumption of and preference for saccharin or sucrose solutions. Preference deficits took at least 2 weeks to develop and were maintained for more than 2 weeks after termination of the stress regime. Sucrose preference was unaffected by 1 week of treatment with the tricyclic antidepressant DMI but returned to normal after 2–4 weeks of DMI treatment. DMI did not alter sucrose preference in unstressed animals. No significant changes were seen in saline preference either during stress or following drug treatment. DMI reduced blood corticosterone and glucose levels, but stress did not significantly alter either measure. The results are discussed in terms of an animal model of endogenous depression.