Clinical markers in adult offspring of families with and without Balkan Endemic Nephropathy.
Clinical markers in adult offspring of families with and without Balkan Endemic Nephropathy.
复制标题
患有和不患有巴尔干地方性肾病的家庭成年后代的临床标志物。
DOI：
10.1038/sj.ki.5000120
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发表时间：
2006
影响因子：
19.6
通讯作者：
Karmaus,W
中科院分区：
文献类型：
--
作者：
Dimitrov,P;Tsolova,S;Georgieva,R;Bozhilova,D;Simeonov,V;Bonev,A;Karmaus,W
巴尔干半岛的地方性肾病（BEN）是一种进展缓慢的肾脏疾病。只有少数研究调查了BEN家族的后代在疾病发作前的肾脏临床标志物。本项目旨在确定与非BEN后代相比，BEN后代的肾功能和结构是否发生改变。研究人群包括102名成年BEN后代和99名非BEN后代的对照组。我们收集了尿液和血液样本，并进行了面对面的访谈，身体检查和肾脏超声测量。测定尿总蛋白、白蛋白、β2-微球蛋白、肌酐、血清肌酐、尿素及肌酐清除率（CCR）。两个风险因素进行了评估：第一，从一个BEN家庭的后代的总体状况，第二，母亲和/或父亲与BEN的具体地位。使用线性回归分析数据。在调整混杂因素后，我们发现BEN后代的肾脏长度和最小皮质宽度显著降低。BEN后代的尿总蛋白、白蛋白和β2-微球蛋白浓度较高。关于父母的病史，只有患有BEN的母亲的后代的相关性具有统计学意义，除了最小皮质宽度，这表明父母没有差异。对于CCR，我们没有发现BEN后代状态或父母病史的统计学显著影响。总之，BEN家族的成年后代的特点是肾脏长度较短，白蛋白、总蛋白和β2-微球蛋白排泄增加，特别是当母亲患有BEN时。
Balkan Endemic Nephropathy (BEN) is a kidney disease that progresses slowly. Only a few studies have investigated renal clinical markers in offspring of BEN families before the onset of the disease. This project aimed to determine whether kidney function and structure are altered in BEN offspring compared with non-BEN offspring. The study population consisted of 102 adult BEN offspring and a control group of 99 non-BEN offspring. We collected urine and blood samples, and conducted face-to-face interviews, physical examinations and ultrasound measurements of the kidney. Total protein, albumin,β2-microglobulin and creatinine in urine, creatinine and urea in serum, and creatinine clearance (CCR) were determined. Two risk factors were assessed: first, the overall status of being an offspring from a BEN family, and second, the specific status of a mother and/or father with BEN. The data were analyzed using linear regression. After adjusting for confounders, we found that kidney length and minimal cortex width in BEN offspring were significantly decreased. Urine concentrations of total protein, albumin, andβ2-microglobulin were higher in BEN offspring. Regarding parental history, the associations were statistically significant only for the offspring of mothers who had BEN, with the exception of minimal cortex width, which showed no parental difference. For CCR, we did not identify a statistically significant effect for BEN offspring status nor for parental history. In conclusion, adult offspring of BEN families can be characterized by shorter kidney length and an increased excretion of albumin, total protein, andβ2-microglobulin, in particular, when the mother had BEN.