A meta-analysis of treatments for perinatal depression.

A meta-analysis of treatments for perinatal depression.
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DOI:
10.1016/j.cpr.2011.03.009
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发表时间:
2011-07
影响因子:
12.8
通讯作者:
Barber, Jacques P.
Barber, Jacques P.
中科院分区:
心理学1区
文献类型:
--
作者:
Sockol, Laura E.;Epperson, C. Neill;Barber, Jacques P.

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这项荟萃分析评估了药物和心理干预治疗围产期抑郁症的疗效。一项系统性综述确定了27项研究,包括开放试验(n=9),准随机试验(n=2)和随机对照试验(n=16),评估从治疗前到治疗后的变化或将这些干预措施与对照组进行比较。在单独的荟萃分析中评估了非对照和对照效应量。从治疗前到治疗后,抑郁症状有显著改善,去除离群值和校正发表偏倚后,未控制的总体效应量(Hedges' g)为1.61。治疗后的症状水平低于提示临床显著症状的临界水平。在治疗后,与对照组相比,干预组的抑郁症状明显减少,去除离群值后的总体控制效应量(Hedges' g)为0.65。个体化心理治疗从治疗前到治疗后的症状变化方面上级优于团体心理治疗。干预措施,包括人际治疗组件被发现有更大的效果大小,与控制条件相比,比干预措施,包括认知行为组件。临床实践和未来的研究结果的影响进行了讨论。
This meta-analysis assessed efficacy of pharmacologic and psychological interventions for treatment of perinatal depression. A systematic review identified 27 studies, including open trials (n=9), quasi-randomized trials (n=2), and randomized controlled trials (n=16) assessing change from pretreatment to posttreatment or comparing these interventions to a control group. Uncontrolled and controlled effect sizes were assessed in separate meta-analyses. There was significant improvement in depressive symptoms from pretreatment to posttreatment, with an uncontrolled overall effect size (Hedges' g) of 1.61 after removal of outliers and correction for publication bias. Symptom levels at posttreatment were below cutoff levels indicative of clinically significant symptoms. At posttreatment, intervention groups demonstrated significantly greater reductions in depressive symptoms compared to control groups, with an overall controlled effect size (Hedges' g) of 0.65 after removal of outliers. Individual psychotherapy was superior to group psychotherapy with regard to changes in symptoms from pretreatment to posttreatment. Interventions including an interpersonal therapy component were found to have greater effect sizes, compared to control conditions, than interventions including a cognitive–behavioral component. Implications of the findings for clinical practice and future research are discussed.
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