CYP1A1 polymorphism in adolescents with polycystic ovary syndrome
CYP1A1 polymorphism in adolescents with polycystic ovary syndrome
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DOI：
10.1016/j.ijgo.2010.07.032
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发表时间：
2011-01-01
影响因子：
3.8
通讯作者：
Aktas, Dilek
中科院分区：
文献类型：
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作者：
Akgul, Sinem;Derman, Orhan;Aktas, Dilek
目的：评估土耳其青少年女性CYP 1A 1 Ile/瓦尔多态性的发生率。研究方法：通过收集土耳其安卡拉44例符合鹿特丹标准的多囊卵巢综合征（PCOS）青少年患者和120例13-18岁健康女性对照的DNA样本，分析CYP 1A 1 Ile/瓦尔多态性。结果如下：与对照组相比，PCOS青少年中CYP 1A 1 Ile/瓦尔基因型频率增加了2.5倍（比值比[OR] 2.54; 95%可信区间[CI] 1.143-5.637; P
Objective: To evaluate the rates of the CYP1A1 Ile/Val polymorphism in Turkish adolescent females. Methods: The CYP1A1 Ile/Val polymorphism was analyzed by collecting DNA samples from 44 adolescents with polycystic ovary syndrome (PCOS) according to the Rotterdam criteria and 120 healthy female controls aged 13-18 years in Ankara, Turkey. Results: There was a 2.5-fold increase in the frequency of the CYP1A1 Ile/Val genotype in adolescents with PCOS compared with the control group (odds ratio [OR] 2.54; 95% confidence interval [CI], 1.143-5.637; P