Intra- and inter-observer reproducibility of volume measurement of knee cartilage segmented from the OAI MR image set using a novel semi-automated segmentation method
Intra- and inter-observer reproducibility of volume measurement of knee cartilage segmented from the OAI MR image set using a novel semi-automated segmentation method
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DOI：
10.1016/j.joca.2009.06.003
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发表时间：
2009-12-01
影响因子：
7
通讯作者：
Kwoh, C. K.
中科院分区：
文献类型：
--
作者：
Bae, K. T.;Shim, H.;Kwoh, C. K.
目的：开发一种基于图割算法的半自动方法，用于从骨关节炎倡议(OAI)数据库的高分辨率膝关节磁共振(MR)图像中分割和体积测量软骨，并评估通过该方法获得的测量的观察者内和观察者间的可重复性。设计：20名Kellgren-Lawrence(KL)分级(从0到IV)的固定屈膝X线片的MR图像选自OAI数据库中的基线双回波稳态(DESS)膝关节MR图像(0.B.1成像数据集)。两名训练有素的放射科医生分别使用半自动方法对膝关节软骨进行了两次分割。计算并比较各节段软骨体积。通过重复测量软骨节段体积的变异系数(CV%)来确定观察者内和观察者间的重复性。受试者还被分为低KL(0，I或II)组和高KL(III或IV)组。结果：观察者1和观察者2的平均(+/-SD)观察者内CV%分别为1.29(+/-1.05)%和1.67(+/-1.14)%。观察者间(+/-SD)变异百分率第1次为1.31(+/-1.26)%，第2次为1.79(+/-1.72)%。S组与S组间差异无统计学意义(P=0.272)，S间差异亦无统计学意义(P=0.353)。观察者1的低KL组的观察者内平均变异系数(CV%)显著小于高KL组(0.83vs1.86%：P=0.025)。两个观察者使用的分割处理时间有显著差异(观察者1比2)：会话1(平均49+/-12比33+/-6分钟)和会话2(49+/-8比32+/-8分钟)。结论：半自动图形切割法可以从膝关节高分辨率3T图像中分割和测量软骨，观察者内和观察者间具有较高的重复性。(C)2009年国际骨性关节炎研究会。爱思唯尔有限公司出版。保留所有权利。
Objective: We developed a semi-automated method based on a graph-cuts algorithm for segmentation and volumetric measurements of the cartilage from high-resolution knee magnetic resonance (MR) images from the Osteoarthritis Initiative (OAI) database and assessed the intra- and inter-observer reproducibility of measurements obtained via this method.Design: MR image sets from 20 subjects of varying Kellgren-Lawrence (KL) grades (from 0 to IV) on fixed flexion knee radiographs were selected from the baseline double-echo and steady-state (DESS) knee MR images in the OAI database (0.B.1 Imaging Data set). Two trained radiologists independently performed the segmentation of knee cartilage twice using the semi-automated method. The volumes of segmented cartilage were computed and compared. The intra- and inter-observer reproducibility were determined by means of the coefficient of variation (CV%) of repeated cartilage segmented volume measurements. The subjects were also divided into the low- (0, I or II) and high-KL (III or IV) groups. The differences in cartilage volume measurements and CV% within and between the observers were tested with t tests.Results: The mean (+/- SD) intra-observer CV% for the 20 cases was 1.29 (+/- 1.05)% for observer 1 and 1.67 (+/- 1.14)% for observer 2, while the mean (+/- SD) inter-observer CV% was 1.31 (+/- 1.26)% for session 1 and 1.79 (+/- 1.72)% for session 2. There was no significant difference between the two intra-observer CV%'s (P = 0.272) and between the two inter-observer CV%'s (P = 0.353). The mean intra-observer CV% of the low-KL group was significantly smaller than that for the high-KL group for observer 1 (0.83 vs 1.86%: P = 0.025). The segmentation processing times used by the two observers were significantly different (observer 1 vs 2): (mean 49 +/- 12 vs 33 +/- 6 min) for session 1 and (49 +/- 8 vs 32 +/- 8 min) for session 2.Conclusion: The semi-automated graph-cuts method allowed us to segment and measure cartilage from high-resolution 3 T MR images of the knee with high intra- and inter-observer reproducibility in subjects with varying severity of CA. (C) 2009 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.