Optimal Serum Selenium Concentrations Are Associated with Lower Depressive Symptoms and Negative Mood among Young Adults
Optimal Serum Selenium Concentrations Are Associated with Lower Depressive Symptoms and Negative Mood among Young Adults
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DOI：
10.3945/jn.114.198010
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发表时间：
2015-01-01
影响因子：
4.2
通讯作者：
Miller, Jody C.
中科院分区：
文献类型：
--
作者：
Conner, Tamlin S.;Richardson, Aimee C.;Miller, Jody C.
背景：有证据表明，低硒状态或可能高硒状态与抑郁情绪有关。本研究的目的是探讨血清硒浓度与青壮年抑郁症状和日常情绪状态之间的关系。方法：对978名17~25岁青壮年的抑郁症状和日常情绪状态进行问卷调查，并用网络日记记录他们每天的积极情绪和消极情绪。采用电感耦合等离子体质谱仪测定血清硒浓度。ANCOVA和回归模型在控制了年龄、性别、种族、BMI和每周酒精摄入量的情况下，测试了血清硒浓度的十分之一与情绪结果之间的线性和曲线相关性。结果：平均+/-SD血清硒浓度为82+/-18mU/L，范围为49-450mU/L。血清硒浓度最低的受试者(62+/-4mU/L；十进制1)和较高的血清硒浓度(110+/-38mU/L；十进制10)的受试者调整后的抑郁症状显著高于血清硒浓度中等的受试者(82+/-1到85+/-1mU/L；十进制6和7)。当硒浓度接近85mUg/L时，抑郁症状最低，消极情绪的模式相似，但更多的是U型。积极情绪与硒呈倒U型关系，但与抑郁症状或消极情绪相比，这种模式的一致性较差。结论：在青壮年，血清硒的最佳范围类似于82-85微克/L，与抑郁症状的风险降低相关。这一范围接近谷胱甘肽过氧化物酶的最大值，这表明未来的研究应该探索将硒与情绪联系起来的抗氧化途径。这项试验在澳大利亚新西兰临床试验注册中心注册为ACTRN12613000773730。
Background: There is evidence that low, and possibly high, selenium status is associated with depressed mood. More evidence is needed to determine whether this pattern occurs in young adults with a wide range of serum concentrations of selenium.Objective: The aim of this study was to determine if serum selenium concentration is associated with depressive symptoms and daily mood states in young adults.Methods: A total of 978 young adults (aged 17-25 y) completed the Center for Epidemiological Studies-Depression scale and reported their negative and positive mood daily for 13 d using an Internet diary. Serum selenium concentration was determined by inductively coupled plasma mass spectrometry. ANCOVA and regression models tested the linear and curvilinear associations between decile of serum selenium concentration and mood outcomes, controlling for age, gender, ethnicity, BMI, and weekly alcohol intake. Smoking and childhood socioeconomic status were further controlled in a subset of participants.Results: The mean +/- SD serum selenium concentration was 82 +/- 18 mu g/L and ranged from 49 to 450 mu g/L. Participants with the lowest serum selenium concentration (62 +/- 4 mu g/L; decile 1) and, to a lesser extent, those with the highest serum selenium concentration (110 +/- 38 mu g/L; decile 10) had significantly greater adjusted depressive symptoms than did participants with midrange serum selenium concentrations (82 +/- 1 to 85 +/- 1 mu g/L; deciles 6 and 7). Depressive symptomatology was lowest at a selenium concentration of similar to 85 mu g/L. Patterns for negative mood were similar but more U-shaped. Positive mood showed an inverse U-shaped association with selenium, but this pattern was less consistent than depressive symptoms or negative mood.Conclusions: In young adults, an optimal range of serum selenium between similar to 82 and 85 mu g/L was associated with reduced risk of depressive symptomatology. This range approximates the values at which glutathione peroxidase is maximal, suggesting that future research should investigate antioxidant pathways linking selenium to mood. This trial was registered with the Australian New Zealand Clinical Trials Registry as ACTRN12613000773730.