Helicobacter pylori CagA: A Critical Destroyer of the Gastric Epithelial Barrier
Helicobacter pylori CagA: A Critical Destroyer of the Gastric Epithelial Barrier
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DOI：
10.1007/s10620-013-2589-x
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发表时间：
2013-02
影响因子：
3.1
通讯作者：
Jia Wu;Song Xu;Yongliang Zhu
中科院分区：
文献类型：
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作者：
Jia Wu;Song Xu;Yongliang Zhu
胃上皮屏障完整性的破坏是许多胃病的病理基础，包括胃肿瘤。幽门螺杆菌毒力因子CagA是胃上皮屏障的主要破坏者之一。来源于不同菌株的CagA蛋白之间存在差异。CAGA转位到胃上皮细胞内，以磷酸化依赖和非磷酸化的方式引起细胞信号通路的显著改变，导致细胞形态改变和宿主细胞上皮屏障损伤，为相关疾病的发生奠定了基础。作为CagA的一种新的致病机制，miRNA参与了胃上皮屏障的重建。两者都根除了h.幽门螺杆菌感染和对CagA诱导的胃上皮屏障损伤的干预可能有助于预防胃肿瘤的发展。
The destruction of the integrity of the gastric epithelial barrier underlies the pathology of many gastric diseases, including gastric tumors. TheHelicobacter pylorivirulence factor CagA is one of the main destroyers of the gastric epithelial barrier. There are differences among CagA proteins that originate from different isolates. CagA translocated into the gastric epithelial cells causes significant changes in cell signaling pathways in phosphorylation-dependent and phosphorylation-independent manners, leading to cell morphological changes and host cell epithelial barrier injury, which lay the foundation for the occurrence of related diseases. As a newly identified pathogenic mechanism of CagA, miRNA is involved in the remodeling of the gastric epithelial barrier. Both the eradication ofH. pyloriinfection and interventions against CagA-induced gastric epithelial barrier lesions may contribute to the prevention of the development of gastric tumors.