The Fc receptor for IgA (FcαRI, CD89)
The Fc receptor for IgA (FcαRI, CD89)
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DOI：
10.1016/j.imlet.2003.11.018
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发表时间：
2004-03-29
影响因子：
4.4
通讯作者：
van Egmond, M
中科院分区：
文献类型：
--
作者：
Otten, MA;van Egmond, M
传统上，IgA被认为是一种非炎性抗体，它可以抑制微生物对粘膜壁的粘附而不引发炎症反应。然而，最近提出了存在于粘膜部位的分泌性IgA （SIgA）和血清IgA的作用之间的二分法。SIgA通过限制病原体的入侵发挥其作为第一道防线的作用。血清IgA反过来可能参与破坏粘膜壁完整性后的炎症反应。已经描述了几种IgA受体。然而，迄今为止最具特征的IgA的原型铁受体FcalphaRI （CD89）是最有可能引发炎症反应的候选者，因为它与SIgA结合较差，但在与血清IgA结合时却能强烈地触发有效的效应功能。本文描述了IgA-FcalphaRI结合的新见解，并讨论了这些相互作用的功能含义。(C) 2003, Elsevier B.V.出版
Traditionally IgA has been regarded as a non-inflammatory antibody, which inhibits adhesion of micro-organisms to the mucosal wall without initiation of inflammatory responses. Recently, however, a dichotomy has been suggested between the actions of secretory IgA (SIgA), which is present at mucosal sites, and serum IgA. SIgA exerts its function as first line of defence by limiting invasion of pathogens. Serum IgA in turn may be engaged in inflammatory responses after breaching of mucosal wall integrity. Several receptors for IgA have been described. However, the-as yet-best characterized prototypic Fe receptor for IgA, FcalphaRI (CD89), is the most likely candidate for initiation of inflammatory responses, as it binds poorly to SIgA, but vigorously triggers potent effector functions upon binding to serum IgA. Here, new insights in IgA-FcalphaRI binding are described and the functional implications of these interactions are discussed. (C) 2003 Published by Elsevier B.V.