Microcirculation and tissue oxygenation in the head and limbs during hyperbaric oxygen treatment
Microcirculation and tissue oxygenation in the head and limbs during hyperbaric oxygen treatment
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DOI：
10.28920/dhm51.4.338-344
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发表时间：
2021-12-01
影响因子：
0.9
通讯作者：
Yagishita, Kazuyoshi
中科院分区：
文献类型：
--
作者：
Yamamoto, Naoki;Takada, Ryohei;Yagishita, Kazuyoshi
介绍：高压氧（HBO）暴露10-15分钟已被证明会减少外周血流量，由于血管收缩。然而，外周血流量减少与高压氧治疗外周循环障碍的疗效之间的关系尚不清楚。据报道，长期接触会产生血管舒张作用，并增加外周血流量。本研究探讨高压氧治疗对血流量和经皮氧分压（TcPO 2）的影响。方法：20名健康志愿者，年龄20-65岁（9名男性）参加了这项研究。所有参与者在253.3 kPa下呼吸氧气60 min。从HBO暴露前到暴露后10 min，用激光多普勒血流仪和TcPO 2连续测量耳、手和脚的外周血流量。结果：HBO暴露开始时，全身各部位的外周血流量下降7-23%，随后缓慢增加。暴露后，每个身体部位的外周血流量增加4-76%。TcPO 2增加了840- 1513%，在曝光期间，并保持升高至少10分钟后exposed.Conclusions：目前的研究结果表明，在HBO治疗的血管收缩是短暂的，即使当存在不抑制组织氧分压增加的发展。这些发现与研究高压氧治疗循环障碍患者外周血流量变化有关。
Introduction: Hyperbaric oxygen (HBO) exposure for 10-15 min has been shown to reduce peripheral blood flow due to vasoconstriction. However, the relationship between decreased peripheral blood flow and the therapeutic effects of HBO treatment on peripheral circulatory disorders remain unknown. Longer exposures have been reported to have vasodilatory effects and increase peripheral blood flow. This study investigated the effect of HBO treatment on blood flow and transcutaneous oxygen pressure (TcPO2).Methods: Twenty healthy volunteers aged 20-65 years (nine males) participated in this study. All participants breathed oxygen for 60 min at 253.3 kPa. Peripheral blood flow using laser Doppler flowmetry and TcPO2 on the ear, hand, and foot were continuously measured from pre-HBO exposure to 10 min post-exposure.Results: Peripheral blood flow in each body part decreased by 7-23% at the beginning of the HBO exposure, followed by a slow increase. Post-exposure, peripheral blood flow increased 4-76% in each body part. TcPO2 increased by 840-1,513% during the exposure period, and remained elevated for at least 10 min after the exposure.Conclusions: The findings of the current study suggest vasoconstriction during HBO treatment is transient, and even when present does not inhibit the development of increased tissue oxygen partial pressure. These findings are relevant to studies investigating changes in peripheral blood flow during HBO treatment in patients with circulatory disorders.