Dementia of the Alzheimer's type and accelerated aging in Down syndrome.
Dementia of the Alzheimer's type and accelerated aging in Down syndrome.
复制标题
DOI：
10.1126/sageke.2005.14.dn1
复制
发表时间：
2005-04-06
期刊：
影响因子：
--
通讯作者：
Silverman, W P
中科院分区：
文献类型：
--
作者：
Devenny, D A;Wegiel, J;Silverman, W P
这项案例研究针对一名患有唐氏综合症和阿尔茨海默氏症型痴呆症（DAT）的女性，追踪了她在11年内的衰退过程，直到57岁去世。详细的神经病理结果也提出。该病例说明了通常与唐氏综合征相关的早衰特征，以及通常与DAT相关的记忆和认知的进行性变化。尽管受试者的心血管疾病和甲状腺疾病得到了治疗，但它们可能导致了她的记忆力下降。这个病例显示了在患有抑郁症和精神病共病发作的精神发育迟滞患者中诊断痴呆的困难。
This case study, of a woman with Down syndrome and dementia of the Alzheimer's type (DAT), follows the course of her decline over an 11-year period until death at age 57. Detailed neuropathological findings are also presented. This case illustrates features of premature aging that are typically associated with Down syndrome, and the progressive changes in memory and cognition that are usually associated with DAT. Although the subject's cardiovascular condition and thyroid disorder were treated, they may have contributed to the decline of her memory. This case shows the difficulty in diagnosing dementia in an individual with mental retardation who suffered comorbid episodes of depression and psychosis.