INDUCTION OF APOPTOTIC CELL-DNA FRAGMENTATION IN HUMAN-CELLS AFTER TREATMENT WITH HYPERTHERMIA
INDUCTION OF APOPTOTIC CELL-DNA FRAGMENTATION IN HUMAN-CELLS AFTER TREATMENT WITH HYPERTHERMIA
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DOI：
10.1016/0304-3835(94)03668-9
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发表时间：
1995-03-02
期刊：
影响因子：
9.7
通讯作者：
ONEILL, KL
中科院分区：
文献类型：
--
作者：
FAIRBAIRN, JJ;KHAN, MW;ONEILL, KL
细胞凋亡的生物学意义越来越清晰。它与肿瘤治疗反应的相关性以及其作为肿瘤发生调节机制的重要功能的最新证据也已得到证实。细胞凋亡最显著的生物学特征之一是核小体DNA断裂。在这篇通讯中，我们提出了一项在Raji细胞中DNA片段化的研究，Raji细胞经过高温治疗诱导凋亡。我们发现破碎的诱导和开始是迅速的，并且与先前的报道一致，破碎必须是一个快速的事件。
The biological significance of apoptosis is becoming increasingly clear. Its relevance in tumor response to treatment as well as recent evidence for its important function as a regulating mechanism in tumorigenesis has also been demonstrated. One of the most prominent biological features of apoptosis is nucleosomal DNA fragmentation. In this communication, we present a study of DNA fragmentation in Raji cells which have been subjected to hyperthermia treatment to induce apoptosis. We found that the induction and onset of fragmentation is swift, and consistent with previous reports that fragmentation must be a rapid event.