1-methyl-4-phenylpyridinium (MPP+) analogs: in vivo neurotoxicity and inhibition of striatal synaptosomal dopamine uptake.
1-methyl-4-phenylpyridinium (MPP+) analogs: in vivo neurotoxicity and inhibition of striatal synaptosomal dopamine uptake.
复制标题
1-甲基-4-苯基吡啶鎓 (MPP ) 类似物：体内神经毒性和纹状体突触体多巴胺摄取的抑制。
DOI：
10.1016/0014-2999(89)90684-5
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发表时间：
1989
影响因子：
5
通讯作者：
CastagnoliJr,N
中科院分区：
文献类型：
--
作者：
Johnson,EA;Wu,EY;Rollema,H;Booth,RG;Trevor,AJ;CastagnoliJr,N
测定了不同1-甲基-4-苯基吡啶（MPP+）类似物抑制C57黑小鼠新纹状体突触体摄取氚标记多巴胺和MPP+的能力，并与脑内微透析技术测定的多巴胺能神经毒性潜力进行了比较。这两个属性之间观察到的相关性表明，神经末梢摄取是MPP+的结构类似物的黑质纹状体毒性的表达中的重要步骤。这一系列化合物的摄取抑制和神经毒性性质似乎是高度结构敏感的，并表明很少的含氮碱基将是有效的1-甲基-4-苯基-1，2，3，6-四氢吡啶（MPTP）型神经毒素。
The ability of various 1-methyl-4-phenylpyridinium (MPP+) analogs to inhibit the uptake of tritium labeled dopamine and MPP+by synaptosomes prepared from neostriata of male C57 Black mice was measured and compared with their dopaminergic neurotoxic potential which was estimated by an in vivo intracerebral microdialysis technique. The correlation observed between these two properties suggests that nerve terminal uptake is an important step in the expression of the nigrostriatal toxicity of structural analogs of MPP+. The uptake inhibition and neurotoxic properties of this series of compounds appear to be highly structurally sensitive and suggest that few nitrogenous bases will be potent 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-type neurotoxins.