Effect of hematopoietic cytokines on renal function in cisplatin-induced ARF in mice
Effect of hematopoietic cytokines on renal function in cisplatin-induced ARF in mice
复制标题
DOI：
10.1016/j.bbrc.2004.09.051
复制
发表时间：
2004-11-05
影响因子：
3.1
通讯作者：
Hamaoka, K
中科院分区：
文献类型：
--
作者：
Nishida, M;Fujimoto, SI;Hamaoka, K
在这项研究中，造血细胞因子，即，本实验观察了粒细胞集落刺激因子（G-CSF）、干细胞因子（SCF）和粒细胞-巨噬细胞集落刺激因子（GM-CSF）对顺铂所致急性肾功能衰竭小鼠肾功能的影响。G-CSF治疗显著改善了顺铂给药引起的BUN和血清肌酐升高，同时减轻了坏死变化的程度，增强了DNA合成，减少了肾小管细胞凋亡。SCF或GM-CSF治疗后，这些参数无显著变化。顺铂和G-CSF联合治疗组小鼠血清肝细胞生长因子水平显著低于单用顺铂组。总之，G-CSF，而不是SCF或GM-CSF，在顺铂诱导的急性肾功能衰竭小鼠中，起到加速肾小管上皮细胞再生和防止凋亡的作用，并导致肾损伤减少。(C)2004年爱思唯尔公司All rights reserved.
In this study, the effect of hematopoietic cytokines, i.e., granulocyte-colony stimulating factor (G-CSF), stem cell factor (SCF), and granulocyte-macrophage-colony stimulating factor (GM-CSF), on renal function was Studied in cisplatin-induced acute renal failure in mice. Treatment with G-CSF significantly ameliorated both BUN and serum creatinine increase induced by cisplatin administration with concomitant alleviation in the degree of necrotic change, enhancement in DNA synthesis, and decrease in apoptosis of renal tubular cells. There was no significant change observed among these parameters following treatment with SCF or with GM-CSF. Serum hepatocyte growth factor level was significantly lower in mice treated with cisplatin and G-CSF compared with that in those treated with cisplatin only. In conclusion, G-CSF, but not SCF or GM-CSF, acts to accelerate regeneration and prevent apoptosis of renal tubular epithelial cells and leads to reduced renal injury in cisplatin-induced acute renal failure in mice. (C) 2004 Elsevier Inc. All rights reserved.