Evolution of drug resistance in tuberculosis: recent progress and implications for diagnosis and therapy.
Evolution of drug resistance in tuberculosis: recent progress and implications for diagnosis and therapy.
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DOI：
10.1007/s40265-014-0248-y
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发表时间：
2014-07
期刊：
影响因子：
11.5
通讯作者：
Gagneux, Sebastien
中科院分区：
文献类型：
--
作者：
Trauner, Andrej;Borrell, Sonia;Reither, Klaus;Gagneux, Sebastien
耐药结核病对全球公共卫生构成日益严重的威胁。最近了解耐药性进化的努力表明，药物与靶标相互作用的变化只是更长适应过程的第一步。传染性耐药结核分枝杆菌的出现是大量额外基因突变的结果，其中许多突变相互作用，这种现象称为上位性。这些上位相互作用的不同影响包括补偿与耐药性发展相关的生物成本的降低、增加耐药性水平，以及可能适应耐药细菌生理学的更广泛变化。对这些过程的了解以及我们在它们发生时检测它们的能力为诊断工具和更好的控制策略的开发提供了信息。特别是，使用全基因组测序与现场监测工作相结合可以为预防未来耐药结核病的流行提供强大的工具。
Drug-resistant tuberculosis is a growing threat to global public health. Recent efforts to understand the evolution of drug resistance have shown that changes in drug–target interactions are only the first step in a longer adaptive process. The emergence of transmissible drug-resistant Mycobacterium tuberculosis is the result of a multitude of additional genetic mutations, many of which interact, a phenomenon known as epistasis. The varied effects of these epistatic interactions include compensating for the reduction of the biological cost associated with the development of drug resistance, increasing the level of resistance, and possibly accommodating broader changes in the physiology of resistant bacteria. Knowledge of these processes and our ability to detect them as they happen informs the development of diagnostic tools and better control strategies. In particular, the use of whole genome sequencing combined with surveillance efforts in the field could provide a powerful instrument to prevent future epidemics of drug-resistant tuberculosis.
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影响因子：
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