Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System.
Sphingosine Kinases and Sphingosine 1-Phosphate Receptors: Signaling and Actions in the Cardiovascular System.
复制标题
鞘氨醇激酶和1-磷酸盐受体：心血管系统中的信号传导和作用。
DOI：
10.3389/fphar.2017.00556
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发表时间：
2017
影响因子：
5.6
通讯作者：
Rengo G
中科院分区：
文献类型：
--
作者：
Cannavo A;Liccardo D;Komici K;Corbi G;de Lucia C;Femminella GD;Elia A;Bencivenga L;Ferrara N;Koch WJ;Paolocci N;Rengo G
鞘氨醇激酶1和2（SphK 1和2）催化脂质鞘氨醇的磷酸化，产生信号传导剂鞘氨醇1-磷酸（S1 P）。这些激酶的激活和随后的S1 P产生和分泌在哺乳动物的血清中代表了许多细胞信号级联中的主要检查点。事实上，激活SphK/S1 P系统对于细胞运动和增殖、细胞骨架组织、细胞生长、存活和对应激的反应至关重要。在心血管系统中，S1 P的生理作用通过结合和激活一个家族的五个高选择性G蛋白偶联受体（称为S1 PR 1 -5）进行干预。重要的是，SphK/S1 P信号存在于血管和心肌细胞上。S1 P是许多组织中公认的存活因子。因此，这并不奇怪，在过去的二十年里，人们对磷脂及其受体（尤其是在心血管系统中）的信号传导以及生物活性产生了浓厚的兴趣和研究努力。在这里，我们将提供一个最新的帐户的结构和功能的鞘氨醇激酶，讨论的产生，释放和功能的S1 P。保持靶心的心血管系统，我们将审查的结构和信号级联和不同的S1 P受体的刺激所产生的生物作用。最后，我们将总结针对S1 PRs和SphKs作为心血管疾病（如心力衰竭）可能的新治疗途径的最新实验和临床观察。
The sphingosine kinases 1 and 2 (SphK1 and 2) catalyze the phosphorylation of the lipid, sphingosine, generating the signal transmitter, sphingosine 1-phosphate (S1P). The activation of such kinases and the subsequent S1P generation and secretion in the blood serum of mammals represent a major checkpoint in many cellular signaling cascades. In fact, activating the SphK/S1P system is critical for cell motility and proliferation, cytoskeletal organization, cell growth, survival, and response to stress. In the cardiovascular system, the physiological effects of S1P intervene through the binding and activation of a family of five highly selective G protein-coupled receptors, called S1PR1-5. Importantly, SphK/S1P signal is present on both vascular and myocardial cells. S1P is a well-recognized survival factor in many tissues. Therefore, it is not surprising that the last two decades have seen a flourishing of interest and investigative efforts directed to obtain additional mechanistic insights into the signaling, as well as the biological activity of this phospholipid, and of its receptors, especially in the cardiovascular system. Here, we will provide an up-to-date account on the structure and function of sphingosine kinases, discussing the generation, release, and function of S1P. Keeping the bull’s eye on the cardiovascular system, we will review the structure and signaling cascades and biological actions emanating from the stimulation of different S1P receptors. We will end this article with a summary of the most recent, experimental and clinical observations targeting S1PRs and SphKs as possible new therapeutic avenues for cardiovascular disorders, such as heart failure.
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影响因子：
4.5
作者：
Argraves KM;Sethi AA;Gazzolo PJ;Wilkerson BA;Remaley AT;Tybjaerg-Hansen A;Nordestgaard BG;Yeatts SD;Nicholas KS;Barth JL;Argraves WS
通讯作者：
Argraves WS
影响因子：
16.6
作者：
Cannavo A;Liccardo D;Eguchi A;Elliott KJ;Traynham CJ;Ibetti J;Eguchi S;Leosco D;Ferrara N;Rengo G;Koch WJ
通讯作者：
Koch WJ
影响因子：
64.5
作者：
Chipuk JE;McStay GP;Bharti A;Kuwana T;Clarke CJ;Siskind LJ;Obeid LM;Green DR
通讯作者：
Green DR
DOI：
10.1124/jpet.115.228411
发表时间：
2016-02-01
影响因子：
3.5
作者：
Cannavo, Alessandro;Liccardo, Daniela;Rengo, Giuseppe
通讯作者：
Rengo, Giuseppe
DOI：
10.1124/jpet.107.133975
发表时间：
2008-03-01
影响因子：
3.5
作者：
Errami, Mounir;Galindo, Cristi L.;Garner, Harold R.
通讯作者：
Garner, Harold R.