Lineage factors and differentiation states in lung cancer progression.
Lineage factors and differentiation states in lung cancer progression.
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肺癌进展中的谱系因素和分化状态。
DOI：
10.1038/onc.2015.85
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发表时间：
2015-11-19
期刊：
影响因子：
8
通讯作者：
Nguyen DX
中科院分区：
文献类型：
--
作者：
Cheung WK;Nguyen DX
肺癌包含一组异质性的恶性肿瘤。在此，我们讨论主要肺癌亚型显著的多样性如何在其起源转化细胞、致癌依赖性、表型可塑性、转移能力以及对治疗的反应中体现出来。更具体地说，我们回顾了越来越多的证据，这些证据潜在地将这种生物学异质性与细胞谱系特异性通路的失调以及最终控制它们的转录因子联系起来。作为肺上皮分化的决定因素，这些特征尚不明确的转录网络可能是不同肺癌的病因和生物学进展的基础，同时为创新治疗策略提供思路。
Lung cancer encompasses a heterogeneous group of malignancies. Here, we discuss how the remarkable diversity of major lung cancer subtypes is manifested in their transforming cell of origin, oncogenic dependencies, phenotypic plasticity, metastatic competence, and response to therapy. More specifically, we review the increasing evidence that potentially links this biological heterogeneity to the de-regulation of cell lineage specific pathways and the transcription factors that ultimately control them. As determinants of pulmonary epithelial differentiation, these poorly characterized transcriptional networks may underlie the etiology and biological progression of distinct lung cancers, while providing insight into innovative therapeutic strategies.
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影响因子：
64.5
作者：
Cheung KJ;Gabrielson E;Werb Z;Ewald AJ
通讯作者：
Ewald AJ
影响因子：
50.5
作者：
Berghmans, T.;Paesmans, M.;Sculier, J. -P.
通讯作者：
Sculier, J. -P.
影响因子：
30.8
作者：
Bass, Adam J.;Watanabe, Hideo;Mermel, Craig H.;Yu, Soyoung;Perner, Sven;Verhaak, Roel G.;Kim, So Young;Wardwell, Leslie;Tamayo, Pablo;Gat-Viks, Irit;Ramos, Alex H.;Woo, Michele S.;Weir, Barbara A.;Getz, Gad;Beroukhim, Rameen;O'Kelly, Michael;Dutt, Amit;Rozenblatt-Rosen, Orit;Dziunycz, Piotr;Komisarof, Justin;Chirieac, Lucian R.;LaFargue, Christopher J.;Scheble, Veit;Wilbertz, Theresia;Ma, Changqing;Rao, Shilpa;Nakagawa, Hiroshi;Stairs, Douglas B.;Lin, Lin;Giordano, Thomas J.;Wagner, Patrick;Minna, John D.;Gazdar, Adi F.;Zhu, Chang Qi;Brose, Marcia S.;Cecconello, Ivan;Ribeiro, Ulysses, Jr.;Marie, Suely K.;Dahl, Olav;Shivdasani, Ramesh A.;Tsao, Ming-Sound;Rubin, Mark A.;Wong, Kwok K.;Regev, Aviv;Hahn, William C.;Beer, David G.;Rustgi, Anil K.;Meyerson, Matthew
通讯作者：
Meyerson, Matthew
影响因子：
11.2
作者：
Allen TD;Rodriguez EM;Jones KD;Bishop JM
通讯作者：
Bishop JM
影响因子：
3.6
作者：
Alam, Naheed;Gustafson, Karen S.;Dudek, Arkadiusz Z.
通讯作者：
Dudek, Arkadiusz Z.