Depressive symptoms during buprenorphine vs. methadone maintenance: findings from a randomised, controlled trial in opioid dependence
Depressive symptoms during buprenorphine vs. methadone maintenance: findings from a randomised, controlled trial in opioid dependence
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DOI：
10.1016/j.eurpsy.2004.09.002
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发表时间：
2004-12-01
影响因子：
7.8
通讯作者：
Mattick, RP
中科院分区：
文献类型：
--
作者：
Dean, AJ;Bell, J;Mattick, RP
研究表明，丁丙诺啡可能具有抗抑郁活性。接受丁丙诺啡或美沙酮维持治疗的海洛因依赖受试者在基线和3个月时完成Beck抑郁量表，这是NDARC（澳大利亚）进行的一项更大、既存、双盲试验的一部分。所有受试者的抑郁症状均得到改善，美沙酮组和丁丙诺啡组之间无差异，表明丁丙诺啡与美沙酮相比对抑郁症状无差异获益。(C)2004年，Elsevier SAS。All rights reserved.
Research suggests that buprenorphine may possess antidepressant activity. The Beck Depression Inventory was completed at baseline and 3 months by heroin dependent subjects receiving either buprenorphine or methadone maintenance as part of a larger, pre-existing, double blind trial conducted by NDARC (Australia). Depressive symptoms improved in all Subjects, with no difference between methadone and buprenorphine groups, suggesting no differential benefit on depressive symptoms for buprenorphine compared to methadone. (C) 2004 Elsevier SAS. All rights reserved.