T-LYMPHOCYTES CD68-POSITIVE CELLS AND VASCULARIZATION IN THYROID CARCINOMAS
T-LYMPHOCYTES CD68-POSITIVE CELLS AND VASCULARIZATION IN THYROID CARCINOMAS
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DOI：
10.1007/bf01245376
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发表时间：
1994-09-01
影响因子：
3.6
通讯作者：
HUBNER, K
中科院分区：
文献类型：
--
作者：
HERRMANN, G;SCHUMMDRAEGER, PM;HUBNER, K
对75例滤泡细胞来源的甲状腺癌进行CD3、CD45RO阳性淋巴细胞和CD68阳性细胞的免疫组织化学检测和定量，发现这些参数与去分化有关。随着分化程度的降低，血管形成减少的趋势变得明显，只有当比较分化良好的滤泡性癌和间变性癌时，统计学上才有显著意义。CD68、CD3、CD45RO阳性细胞密度以及CD68、CD3、CD45RO阳性细胞密度与血管形成呈正相关。这些相关性是预期的，因为CD68阳性细胞和T淋巴细胞的相互作用导致血管生成因子的产生，最终导致更好的肿瘤血管形成。然而，肿瘤细胞本身产生血管生成物质的能力各不相同。在这项研究中确定的肿瘤浸润性细胞密度和血管形成之间明显缺乏正相关性，尽管减少了。在分化较低的肿瘤中，含有越来越多的肿瘤浸润性细胞的血管形成，似乎是由于形态相似的肿瘤的功能异质性所致。
Immunohistochemical detection and quantification of CD3- and CD45RO-positive lymphocytes and CD68-positive cells in 75 thyroid carcinomas of follicular cell origin revealed rising levels for these parameters associated with dedifferentiation. A parallel trend towards reduction of vascularisation, determined as CD31-positive blood vessels, with decreasing differentiation became evident, statistically only significant when well-differentiated follicular and anaplastic carcinomas were compared. Positive correlations could be demonstrated between the density of CD68-, CD3-, and CD45RO-positive cells as well as between the density of CD68-, and CD3-, and CD45RO-positive cells and vascularisation. These correlations were expected, as the interaction of CD68-positive cells and T lymphocytes results in the production of angiogenesis factors, ultimately leading to better vascularisation of the tumour. Nevertheless, the tumour cells themselves are variously capable of producing angiogenic substances. The obvious lack of positive correlation between the density of tumour-infiltrating cells determined in this study and vascularisation, despite reduced. vascularisation in less differentiated tumours that contained increasing numbers of tumour-infiltrating cells, seems to be due to functional heterogeneity of morphologically similar tumours.