Developmental Maturation of the Precuneus as a Functional Core of the Default Mode Network
Developmental Maturation of the Precuneus as a Functional Core of the Default Mode Network
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DOI：
10.1162/jocn_a_01426
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发表时间：
2019-10-01
影响因子：
3.2
通讯作者：
van Duijvenvoorde, Anna C. K.
中科院分区：
文献类型：
--
作者：
Li, Rosa;Utevsky, Amanda V.;van Duijvenvoorde, Anna C. K.
绘制发育中的人类大脑的功能结构的努力表明，功能神经网络之间和内部的连接从儿童到成年都在变化。尽管先前的工作已经确定，成年楔前叶在任务与休息状态期间明显改变其连接性[Utevsky，A.五、史密斯，D.五、& Huettel，S. A.楔前叶是默认模式网络的功能核心。Journal of Neuroscience，34，932-940，2014]，仍然不知道这些连接模式如何在发育过程中出现。在这里，我们使用功能磁共振成像数据收集在两个纵向时间点，从250名参与者之间的8和26岁从事两个认知任务和静息状态扫描。通过对任务和休息数据进行独立成分分析，我们确定了三个典型的感兴趣的网络-基于休息的默认模式网络和基于任务的左额顶和右额顶网络（LFPN和RFPN，分别）-我们使用双回归分析探索了发展变化。我们发现系统的状态依赖功能连接楔前叶，这样，从事一项任务（与休息相比）导致更大的楔前叶LFPN和楔前叶RFPN连接，而在休息（与任务相比）导致更大的楔前叶默认模式网络连接。这些横断面结果在两个任务和两个发展时间点上都是重复的。最后，我们使用纵向混合模型表明，楔前叶区分任务和休息状态的程度随着年龄的增长而增加，由于年龄相关的楔前叶和LFPN之间的隔离在休息。我们的研究结果突出了楔前叶在跟踪处理状态中的独特作用，其方式是贯穿整个开发过程并得到加强。
Efforts to map the functional architecture of the developing human brain have shown that connectivity between and within functional neural networks changes from childhood to adulthood. Although prior work has established that the adult precuneus distinctively modifies its connectivity during task versus rest states [Utevsky, A. V., Smith, D. V., & Huettel, S. A. Precuneus is a functional core of the default-mode network. Journal of Neuroscience, 34, 932-940, 2014], it remains unknown how these connectivity patterns emerge over development. Here, we use fMRI data collected at two longitudinal time points from over 250 participants between the ages of 8 and 26 years engaging in two cognitive tasks and a resting-state scan. By applying independent component analysis to both task and rest data, we identified three canonical networks of interest-the rest-based default mode network and the task-based left and right frontoparietal networks (LFPN and RFPN, respectively)-which we explored for developmental changes using dual regression analyses. We found systematic state-dependent functional connectivity in the precuneus, such that engaging in a task (compared with rest) resulted in greater precuneus-LFPN and precuneus-RFPN connectivity, whereas being at rest (compared with task) resulted in greater precuneus-default mode network connectivity. These cross-sectional results replicated across both tasks and at both developmental time points. Finally, we used longitudinal mixed models to show that the degree to which precuneus distinguishes between task and rest states increases with age, due to age-related increasing segregation between precuneus and LFPN at rest. Our results highlight the distinct role of the precuneus in tracking processing state, in a manner that is both present throughout and strengthened across development.