Drug Effect of Thulium(III)-Arsenazo III Complex on Herring Sperm DNA
Drug Effect of Thulium(III)-Arsenazo III Complex on Herring Sperm DNA
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铥(III)-胂III复合物对鲱鱼精子DNA的药物作用
DOI：
10.1155/2018/7232793
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发表时间：
2018-01-01
影响因子：
3
通讯作者：
Wang, Suqin
中科院分区：
文献类型：
--
作者：
Li, Hongbo;Lei, Shutao;Wang, Suqin
为了评价钍（Ⅲ）-偶氮胂Ⅲ配合物作为稀土配合物抗肿瘤药物探针的潜在细胞抑制作用，采用光谱、粘度和伏安法研究了钍（Ⅲ）-偶氮胂Ⅲ配合物与DNA的相互作用.热力学函数表明，配合物与DNA的结合常数分别为Kθ298.15K = 4.84 × 106 L·mol-1和Kθ308.15K = 4.48 × 106 L·mol-1，结合过程为焓驱动.配合物的加入使DNA的相对粘度增加，Scatchard法和伏安法的结果表明配合物与DNA的作用方式为沿着弱的插层结合。
To assess the potential cytostatic properties of the thulium(III)-arsenazo III complex as a probe of rare earth complex antitumor drugs, the interaction information of the thulium(III)-arsenazo III complex with DNA was obtained by using spectroscopy, viscosity measurements, and voltammetric methods. The thermodynamic functions demonstrated that the binding constants of the thulium(III)-arsenazo III complex with DNA were Kθ298.15K = 4.84 × 106 L·mol−1 and Kθ308.15K = 4.48 × 106 L·mol−1, and the binding process was enthalpy driven. The increase in relative viscosity of DNA with the addition of the thulium(III)-arsenazo III complex and the results from Scatchard and voltammetric methods showed that the interaction mode between the thulium(III)-arsenazo III complex and DNA was groove binding along with weak intercalative binding.