Role of non-coding RNAs in tumor progression and metastasis in pancreatic cancer.
Role of non-coding RNAs in tumor progression and metastasis in pancreatic cancer.
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DOI：
10.1007/s10555-021-09995-x
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发表时间：
2021-09
期刊：
影响因子：
--
通讯作者：
Schmittgen TD
中科院分区：
文献类型：
--
作者：
Sempere LF;Powell K;Rana J;Brock AA;Schmittgen TD
胰腺导管腺癌 (PDAC) 是最致命的癌症类型之一，总体 5 年生存率低于 10%。局部晚期或转移性疾病患者的 1 年生存率非常低。癌细胞的侵袭性、血管形成不足、广泛的促纤维增生性基质和免疫抑制肿瘤微环境（TME）赋予PDAC肿瘤多种耐药机制。由于没有明显的基因突变驱动肿瘤进展或转移转变，理解这些过程的生物学机制的挑战是至关重要的。更好地了解这些过程的分子和细胞机制可能会带来用于患者管理的新诊断工具和治疗干预的新目标。 microRNA (miRNA) 是一类进化上保守的短非编码调节 RNA 基因。 miRNA 是一个广泛的调控层，在转录后水平控制基因表达。本综述重点关注在功能上剖析 PDAC 肿瘤进展或转移过程中 miRNA 活性的临床前模型。总的来说，这些研究表明 miRNA 和 RNA-RNA 网络对上皮细胞向间充质细胞转变和癌细胞干性的过程产生影响。在细胞类型水平上，一些 miRNA 主要影响癌细胞的内在过程和途径，而其他 miRNA 主要在 TME 的不同细胞区室中发挥作用，调节成纤维细胞和免疫细胞功能和/或通过细胞外囊泡转移通过细胞间通讯影响其他细胞类型的功能。在分子水平上，miRNA介导的调节的影响通常集中在核心信号通路中，包括TGF-β、JAK/STAT、PI3K/AKT和NF-κB。
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal types of cancer with an overall 5-year survival rate of less than 10%. The 1-year survival rate of patients with locally advanced or metastatic disease is abysmal. The aggressive nature of cancer cells, hypovascularization, extensive desmoplastic stroma, and immunosuppressive tumor microenvironment (TME) endows PDAC tumors with multiple mechanisms of drug resistance. With no obvious genetic mutation(s) driving tumor progression or metastatic transition, the challenges for understanding the biological mechanism(s) of these processes are paramount. A better understanding of the molecular and cellular mechanisms of these processes could lead to new diagnostic tools for patient management and new targets for therapeutic intervention. microRNAs (miRNAs) are an evolutionarily conserved gene class of short non-coding regulatory RNAs. miRNAs are an extensive regulatory layer that controls gene expression at the posttranscriptional level. This review focuses on preclinical models that functionally dissect miRNA activity in tumor progression or metastatic processes in PDAC. Collectively, these studies suggest an influence of miRNAs and RNA-RNA networks in the processes of epithelial to mesenchymal cell transition and cancer cell stemness. At a cell-type level, some miRNAs mainly influence cancer cell–intrinsic processes and pathways, whereas other miRNAs predominantly act in distinct cellular compartments of the TME to regulate fibroblast and immune cell functions and/or influence other cell types’ function via cell-to-cell communications by transfer of extracellular vesicles. At a molecular level, the influence of miRNA-mediated regulation often converges in core signaling pathways, including TGF-β, JAK/STAT, PI3K/AKT, and NF-κB.
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影响因子：
2.9
作者：
Azevedo-Pouly AC;Sutaria DS;Jiang J;Elgamal OA;Amari F;Allard D;Grippo PJ;Coppola V;Schmittgen TD
通讯作者：
Schmittgen TD
影响因子：
4
作者：
Deng S;Wang J;Zhang L;Li J;Jin Y
通讯作者：
Jin Y
影响因子：
28.2
作者：
Elyada, Ela;Bolisetty, Mohan;Tuveson, David A.
通讯作者：
Tuveson, David A.
DOI：
10.1186/s13046-019-1436-0
发表时间：
2019-11-12
影响因子：
11.3
作者：
Chen, Yan;Li, Zhonghu;Wang, Shuguang
通讯作者：
Wang, Shuguang
影响因子：
7.4
作者：
Ensink E;Sinha J;Sinha A;Tang H;Calderone HM;Hostetter G;Winter J;Cherba D;Brand RE;Allen PJ;Sempere LF;Haab BB
通讯作者：
Haab BB