Regulation of transcription by MAP kinase cascades

Regulation of transcription by MAP kinase cascades
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DOI:
10.1016/s0955-0674(96)80067-6
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发表时间:
1996-04-01
影响因子:
7.5
通讯作者:
Treisman, R
Treisman, R
中科院分区:
生物学2区
文献类型:
--
作者:
Treisman, R

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属于丝裂原活化蛋白激酶(MAPK)家族的激酶在整个进化过程中用于控制细胞对外部信号如生长因子、营养状态、应激或诱导信号的反应。MAPK的许多重要底物是转录因子,并且MAPK和转录因子之间的遗传和生物化学联系正变得越来越好理解。
Kinases belonging to the mitogen-activated protein kinase (MAPK) family are used throughout evolution to control the cellular responses to external signals such as growth factors, nutrient status, stress or inductive signals. Many important substrates for MAPKs are transcription factors, and both the genetic and the biochemical links between MAPKs and transcription factors are becoming increasingly well understood.